Higher O-GlcNAc levels are associated with defects in progenitor proliferation and premature neuronal differentiation during in-vitro human embryonic cortical neurogenesis

• Main Authors: Parween, S, Varghese, D.S, Ardah, M.T, Prabakaran, A.D, Mensah-Brown, E, Emerald, B.S, Ansari, S.A
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: 4 [4 (1,3 benzodioxol 5 yl) 5 (2 pyridinyl) 1h imidazol 2 yl]benzamide; 6 [4 (1 piperazinyl)phenyl] 3 (4 quinolinyl)pyrazolo[1,5 a]pyrimidine; beta tubulin; brain derived neurotrophic factor; catechol methyltransferase; doublecortin; metabotropic receptor 4; n acetylglucosamine; octamer transcription factor 4; oxytocin receptor; protein; protein kinase B; reelin; suppressor of tumorigenicity protein 7; T box brain 1 transcription factor; T box brain 2 transcription factor; transcription factor; transcription factor EMX2; transcription factor FOXG1; transcription factor FOXP2; transcription factor NANOG; transcription factor Otx2; transcription factor PAX6; transcription factor POU3F2; transcription factor Sox2; unclassified drug; vesicular glutamate transporter 1; animal experiment; animal model; apoptosis; Article; brain cell; cell proliferation; controlled study; embryo; gene expression; genetic transcription; human; human cell; human embryonic stem cell; hyperglycemia; immunocytochemistry; in vitro study; mental disease; nerve cell differentiation; nervous system development; neural stem cell; nonhuman; phosphorylation; polyacrylamide gel electrophoresis; protein expression; protein modification; rat; real time polymerase chain reaction; RNA isolation; Western blotting; Wistar rat
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181230
• Institution: National University of Singapore

10.3389/fncel.2017.00415