Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment

• Main Authors: Wang, Z, Henn, B.C, Wang, C, Wei, Y, Su, L, Sun, R, Chen, H, Wagner, P.J, Lu, Q, Lin, X, Wright, R, Bellinger, D, Kile, M, Mazumdar, M, Tellez-Rojo, M.M, Schnaas, L, Christiani, D.C
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: lead; cell surface receptor; pollutant; transcriptome; UNC5H4 protein, human; biological development; blood; child health; chromosome; concentration (composition); ecosystem health; environmental factor; gene; genome; genotype-environment interaction; neurology; oxidative stress; poisoning; pollution exposure; polymorphism; toxicity; adult; allele; Article; Bangladesh; Bangladeshi; Bayley Scales of Infant Development; child; chromosome 8; controlled study; developmental stage; environmental exposure; excitotoxicity; female; gene expression profiling; gene locus; genetic susceptibility; genetic variability; genome analysis; genotype environment interaction; human; human cell; in vitro study; lead blood level; male; Mexican; Mexico; nerve cell differentiation; neural stem cell; prenatal exposure; priority journal; scoring system; single nucleotide polymorphism; SLC1A5 gene; transcriptomics; umbilical cord blood; UNC5D gene; chemistry; child development; drug effects; fetus blood; genetics; infant; metabolism; newborn; pregnancy; preschool child; prospective study; Mexico [North America]; Child Development; Child, Preschool; Environmental Pollutants; Female; Fetal Blood; Gene-Environment Interaction; Humans; Infant; Infant, Newborn; Lead; Male; Neural Stem Cells; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Receptors, Cell Surface; Transcriptome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181259
• Institution: National University of Singapore

10.1186/s12940-017-0288-3