Neuroimaging basis in the conversion of aMCI patients with APOE-ε4 to AD: Study protocol of a prospective diagnostic trial

• Main Authors: Chen, G.-Q, Sheng, C, Li, Y.-X, Yu, Y, Wang, X.-N, Sun, Y, Li, H.-Y, Li, X.-Y, Xie, Y.-Y, Han, Y
• Other Authors: LIFE SCIENCES INSTITUTE
• Format: Article
• Published: 2020
• Subjects: apolipoprotein E4; biological marker; Addenbrook cognitive examination revised; Alzheimer disease; APOE epsilon 4 gene; Article; Clinical Dementia Rating scale; clinical protocol; controlled study; diffusion tensor imaging; follow up; functional magnetic resonance imaging; genotype; human; image analysis; longitudinal study; major clinical study; mild cognitive impairment; Mini Mental State Examination; Montreal cognitive assessment; neuroimaging; neuropsychological test; nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; prospective study; resting state functional magnetic resonance imaging; sample size; structural magnetic resonance imaging; study design; World Health Organization-University of California Los Angeles Auditory Verbal Learning Test; China; cognitive defect; diagnostic imaging; disease course; functional neuroimaging; genetics; image processing; procedures; psychology; Alzheimer Disease; Apolipoprotein E4; Biomarkers; Cognitive Dysfunction; Diffusion Tensor Imaging; Disease Progression; Follow-Up Studies; Functional Neuroimaging; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Neuropsychological Tests; Prospective Studies
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181368
• Institution: National University of Singapore

10.1186/s12883-016-0587-2