EGFR Mutant Structural Database: Computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib

• Main Authors: Ma, L, Wang, D.D, Huang, Y, Yan, H, Wong, M.P, Lee, V.H.F
• 其他作者: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• 格式: Article
• 出版: 2020
• 主題: Amino acids; Biological organs; Database systems; Diseases; Drug therapy; Free energy; Binding free energy; Epidermal growth factor receptors; Erlotinib; Gefitinib; Non small cell lung cancer; Tyrosine kinase inhibitor; Binding energy; antineoplastic agent; epidermal growth factor receptor; erlotinib; gefitinib; protein binding; protein kinase inhibitor; quinazoline derivative; chemistry; exon; genetics; human; lung tumor; metabolism; molecular dynamics; mutation; non small cell lung cancer; protein conformation; protein database; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Databases, Protein; Erlotinib Hydrochloride; Exons; Humans; Lung Neoplasms; Molecular Dynamics Simulation; Mutation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Quinazolines; Receptor, Epidermal Growth Factor
• 在線閱讀: https://scholarbank.nus.edu.sg/handle/10635/181411

10.1186/s12859-015-0522-3