Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults

• Main Authors: Gillard, P, Chu, D.W.S, Hwang, S.-J, Yang, P.-C, Thongcharoen, P, Lim, F.S, Dramé, M, Walravens, K, Roman, F
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: CD4 antibody; CD40 ligand; gamma interferon; immunological adjuvant; influenza vaccine; interleukin 2; tumor necrosis factor alpha; neutralizing antibody; acute kidney failure; adult; antibody response; antibody titer; appendicitis; article; Asian; avian influenza; benign tumor; brain disease; CD8+ T lymphocyte; cellular immunity; clavicle fracture; colon polyp; controlled study; drug safety; drug tolerability; drug withdrawal; face fracture; fatigue; female; flu like syndrome; Helicobacter infection; hemagglutination inhibition test; Hong Kong; human; humoral immunity; ileus; immune response; immunogenicity; immunoreactivity; influenza A (H5N1); Influenza virus A H5N1; injection site pain; joint dislocation; ligament rupture; lung embolism; lymphadenopathy; major clinical study; male; myalgia; ovary tumor; pandemic influenza; phase 3 clinical trial; pyelonephritis; rhinopharyngitis; Singapore; Taiwan; Thailand; tonsillitis; tooth disease; vaccination; virus neutralization; virus strain; Article; cross reaction; evaluation study; influenza vaccination; injection site reaction; open study; randomized controlled trial; Adult; alpha-Tocopherol; Animals; Antibodies, Neutralizing; Antibodies, Viral; Asian Continental Ancestry Group; Cross Reactions; Drug Combinations; Female; Humans; Immunization Schedule; Immunization, Secondary; Influenza A Virus, H5N1 Subtype; Influenza Vaccines; Male; Middle Aged; Polysorbates; Squalene; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181506
• Institution: National University of Singapore

10.1186/1471-2334-14-142