The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

• Main Authors: Combarros, O, Warden, D.R, Hammond, N, Cortina-Borja, M, Belbin, O, Lehmann, M.G, Wilcock, G.K, Brown, K, Kehoe, P.G, Barber, R, Coto, E, Alvarez, V, Deloukas, P, Gwilliam, R, Heun, R, Kölsch, H, Mateo, I, Oulhaj, A, Arias-Vásquez, A, Schuur, M, Aulchenko, Y.S, Ikram, M.A, Breteler, M.M, van Duijn, C.M, Morgan, K, Smith, A.D, Lehmann, D.J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: dopamine beta monooxygenase; interleukin 1alpha; interleukin 6; noradrenalin; IL1A protein, human; aged; allele; Alzheimer disease; article; controlled study; factorial analysis; female; gene interaction; genetic association; genetic epistasis; genetic risk; genotype; human; inflammation; logistic regression analysis; major clinical study; male; regulatory mechanism; single nucleotide polymorphism; Europe; genetics; locus ceruleus; nerve cell; pathology; risk; risk factor; Spain; Aged; Alzheimer Disease; Dopamine beta-Hydroxylase; Epistasis, Genetic; Female; Genotype; Humans; Interleukin-1alpha; Interleukin-6; Locus Coeruleus; Male; Neurons; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181653
• Institution: National University of Singapore

10.1186/1471-2350-11-162