Vancomycin versus daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia due to isolates with high vancomycin minimum inhibitory concentrations: Study protocol for a phase IIB randomized controlled trial

• Main Authors: Kalimuddin, S, Phillips, R, Gandhi, M, de Souza, N.N, Low, J.G.H, Archuleta, S, Lye, D, Tan, T.T
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: daptomycin; vancomycin; antiinfective agent; adult; antibiotic therapy; article; bacterium isolate; blood culture; bloodstream infection; clinical article; comparative effectiveness; controlled study; drug efficacy; drug safety; female; hospital patient; human; intention to treat analysis; male; methicillin resistant Staphylococcus aureus; methicillin resistant Staphylococcus aureus infection; minimum inhibitory concentration; mortality; multicenter study (topic); open study; phase 2 clinical trial (topic); pilot study; prospective study; randomized controlled trial (topic); staphylococcal bacteremia; bacteremia; clinical trial; comparative study; drug administration; drug effects; methodology; microbial sensitivity test; multicenter study; phase 2 clinical trial; randomized controlled trial; Staphylococcal Infections; young adult; Anti-Bacterial Agents; Bacteremia; Daptomycin; Drug Administration Schedule; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Pilot Projects; Prospective Studies; Research Design; Vancomycin; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181750
• Institution: National University of Singapore

10.1186/1745-6215-15-233