Low-dose insulin-like growth factor binding proteins 1 and 2 and angiopoietin-like protein 3 coordinately stimulate ex vivo expansion of human umbilical cord blood hematopoietic stem cells as assayed in NOD/SCID gamma null mice

• Main Authors: Fan, X, Gay, F.P, Lim, F.W, Ang, J.M, Chu, P.P, Bari, S, Hwang, W.Y
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: angiopoietin; angiopoietin like protein 3; somatomedin binding protein 1; somatomedin binding protein 2; stem cell factor; thrombopoietin; unclassified drug; ANGPTL3 protein, human; IGF2 protein, human; IGFBP-2 protein, human; IGFBP1 protein, human; somatomedin B; animal cell; animal experiment; animal model; article; bone marrow; controlled study; correlation analysis; cryopreservation; dilution; ex vivo study; hematopoiesis; hematopoietic stem cell; human; human cell; in vivo study; mesenchymal stroma cell; mononuclear cell; mouse; NOD SCID gamma mouse; nonhuman; priority journal; stem cell expansion; umbilical cord blood; animal; culture technique; cytology; drug effects; fetus blood; hematopoietic stem cell transplantation; nonobese diabetic mouse; procedures; SCID mouse; Mus; Angiopoietins; Animals; Cell Culture Techniques; Fetal Blood; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor II; Mice; Mice, Inbred NOD; Mice, SCID
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181754
• Institution: National University of Singapore

10.1186/scrt460