TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

• Main Authors: Mitrovic, S, Nogueira, C, Cantero-Recasens, G, Kiefer, K, Fernández-Fernández, J.M, Popoff, J.-F, Casano, L, Bard, F.A, Gomez, R, Valverde, M.A, Malhotra, V
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: 2020
• Subjects: activating transcription factor 6; chemokine receptor CCR9; chemokine receptor CX3CR1; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; mitogen activated protein kinase; mucin 5AC; natural cytotoxicity triggering receptor 1; obscurin; sodium channel Nav1.2; sodium channel Nav1.3; sulfonylurea receptor 1; transient receptor potential channel M5; calcium; mucin; phorbol 13 acetate 12 myristate; transient receptor potential channel M; TRPM5 protein, human; article; calcium transport; cell differentiation; colon; controlled study; dot hybridization; electrophysiology; goblet cell; human; human cell; immunofluorescence microscopy; immunofluorescence test; polyacrylamide gel electrophoresis; protein analysis; protein expression; protein secretion; protein synthesis regulation; real time polymerase chain reaction; cytology; drug effects; Golgi complex; metabolism; physiology; secretion (process); Calcium; Colon; Goblet Cells; Golgi Apparatus; Humans; Mucins; Tetradecanoylphorbol Acetate; TRPM Cation Channels
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182050
• Institution: National University of Singapore

10.7554/eLife.00658