Inactivation of TGF? receptors in stem cells drives cutaneous squamous cell carcinoma

• Main Authors: Cammareri, P, Rose, A.M, Vincent, D.F, Wang, J, Nagano, A, Libertini, S, Ridgway, R.A, Athineos, D, Coates, P.J, McHugh, A, Pourreyron, C, Dayal, J.H.S, Larsson, J, Weidlich, S, Spender, L.C, Sapkota, G.P, Purdie, K.J, Proby, C.M, Harwood, C.A, Leigh, I.M, Clevers, H, Barker, N, Karlsson, S, Pritchard, C, Marais, R, Chelala, C, South, A.P, Sansom, O.J, Inman, G.J
• Other Authors: DEPT OF BIOCHEMISTRY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: B Raf kinase; K ras protein; mitogen activated protein kinase; Smad2 protein; Smad3 protein; Smad4 protein; transforming growth factor beta receptor 1; transforming growth factor beta receptor 2; antineoplastic agent; indole derivative; protein p21; protein p53; protein serine threonine kinase; sulfonamide; TGF-beta type I receptor; transforming growth factor beta; transforming growth factor beta receptor; transforming growth factor-beta type II receptor; vemurafenib; cancer; cells and cell components; cytology; gene; genetic engineering; mutation; protein; rodent; skin; tumor; animal experiment; animal model; animal tissue; Article; controlled study; disease course; extracellular matrix; female; gene mutation; human; human tissue; male; mouse; nonhuman; signal transduction; skin carcinogenesis; skin carcinoma; stem cell; animal; antagonists and inhibitors; biopsy; carcinogenesis; chemically induced; dna mutational analysis; drug effect; experimental neoplasm; genetics; inbred mouse strain; melanoma; metabolism; pathology; procedures; skin tumor; squamous cell carcinoma; tumor cell line; whole exome sequencing; Murinae; Animals; Antineoplastic Agents; Biopsy; Carcinogenesis; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Mutational Analysis; Female; Humans; Indoles; Male; Melanoma; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Experimental; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Receptors, Transforming Growth Factor beta; Signal Transduction; Skin Neoplasms; Stem Cells; Sulfonamides; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Whole Exome Sequencing
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182434
• Institution: National University of Singapore

10.1038/ncomms12493