Dengue virus-infected dendritic cells, but not monocytes, activate natural killer cells through a contact-dependent mechanism involving adhesion molecules

• Main Authors: Costa, V.V, Ye, W, Chen, Q, Teixeira, M.M, Preiser, P, Ooi, E.E, Chen, J
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: American Society for Microbiology 2020
• Subjects: 2beta4; CD2 antigen; CD69 antigen; cell adhesion molecule; DNAM 1; gamma interferon; lymphocyte function associated antigen 1; OX40 ligand; unclassified drug; IL2RA protein, human; interleukin 2 receptor alpha; lectin; leukocyte antigen; T lymphocyte antigen; animal tissue; Article; cell contact; cell interaction; cell protection; controlled study; cytokine release; dendritic cell; dengue; disease association; disease severity; female; human; human cell; in vitro study; in vivo study; liver injury; lymphocyte activation; lymphocyte depletion; lymphocyte function; monocyte; mouse; natural killer cell; nonhuman; priority journal; thrombocytopenia; upregulation; viremia; virus replication; animal; antagonists and inhibitors; Dengue virus; genetics; immunology; liver; metabolism; pathology; SCID mouse; virology; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Adhesion Molecules; Dendritic Cells; Dengue; Dengue Virus; Humans; Interferon-gamma; Interleukin-2 Receptor alpha Subunit; Killer Cells, Natural; Lectins, C-Type; Liver; Lymphocyte Activation; Mice; Mice, SCID; Monocytes; Thrombocytopenia; Viremia; Virus Replication
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183515
• Institution: National University of Singapore

10.1128/mBio.00741-17