Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

• Main Authors: Nguyen, P.N.N, Huang, C.-J, Sugii, S, Cheong, S.K, Choo, K.B
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: BMC 2020
• Subjects: caspase 8; microRNA; microRNA 302; microRNA 372; protein Bak; protein Bax; unclassified drug; adipose derived stem cell; apoptosis; Article; bioinformatics; cancer cell; cancer stem cell; carcinogenesis; cell line; cell survival; chromosome 19; controlled study; embryonic stem cell; enzyme activation; gene activation; gene cluster; gene dosage; gene expression; gene expression profiling; gene function; gene repression; human; human cell; induced pluripotent stem cell; mesenchymal stem cell; microarray analysis; multigene family; nuclear reprogramming; nucleotide sequence; primate; re-adipocyte cell line; regulatory mechanism; signal transduction; transcription regulation; animal; biosynthesis; copy number variation; gene expression regulation; genetics; mesenchymal stroma cell; metabolism; neoplasm; Animals; Apoptosis; Carcinogenesis; Chromosomes, Human, Pair 19; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Humans; Mesenchymal Stromal Cells; MicroRNAs; Multigene Family; Neoplasms; Primates
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183542
• Institution: National University of Singapore

10.1186/s12929-017-0326-z