Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle

10.1021/bi401270d

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Main Authors:	Bell, N.M, L'Hernault, A, Murat, P, Richards, J.E, Lever, A.M.L, Balasubramanian, S
Other Authors:	MEDICINE
Format:	Article
Published:	American Chemical Society 2020
Subjects:	Diseases Genes Life cycle Molecules Proteins Viruses H NMR spectroscopy Human immunodeficiency virus type-1 Inhibitory activity RNA-protein interactions Structural elements Structural proteins Therapeutic targets Viral replication RNA Gag protein structural protein virus protein virus RNA anti human immunodeficiency virus agent molecular library NSC-260594 quinoline derivative ribonucleoprotein Schiff base spliced leader RNA NSC 260594 5' untranslated region article controlled study human human cell Human immunodeficiency virus 1 in vitro study life cycle stage molecule nonhuman priority journal protein expression protein RNA binding proton nuclear magnetic resonance virus genome virus infectivity virus particle virus replication antagonists and inhibitors binding site cell survival chemical structure chemistry conformation DNA denaturation drug effects drug screening HEK293 cell line HeLa cell line HIV Infections metabolism molecularly targeted therapy osmolarity physiology cell strain HEK293 drug antagonism drug effect HeLa cell Human immunodeficiency virus infection Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183903
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1839032024-11-09T14:03:03Z Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle Bell, N.M L'Hernault, A Murat, P Richards, J.E Lever, A.M.L Balasubramanian, S MEDICINE Diseases Genes Life cycle Molecules Proteins Viruses H NMR spectroscopy Human immunodeficiency virus type-1 Inhibitory activity RNA-protein interactions Structural elements Structural proteins Therapeutic targets Viral replication RNA Gag protein structural protein virus protein virus RNA anti human immunodeficiency virus agent molecular library NSC-260594 quinoline derivative ribonucleoprotein Schiff base spliced leader RNA virus RNA anti human immunodeficiency virus agent Gag protein NSC 260594 ribonucleoprotein spliced leader RNA 5' untranslated region article controlled study human human cell Human immunodeficiency virus 1 in vitro study life cycle stage molecule nonhuman priority journal protein expression protein RNA binding proton nuclear magnetic resonance virus genome virus infectivity virus particle virus replication antagonists and inhibitors binding site cell survival chemical structure chemistry conformation DNA denaturation drug effects drug screening HEK293 cell line HeLa cell line HIV Infections Human immunodeficiency virus 1 metabolism molecular library molecularly targeted therapy osmolarity physiology cell strain HEK293 drug antagonism drug effect HeLa cell Human immunodeficiency virus infection virus replication Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV Infections HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV Infections HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication 10.1021/bi401270d Biochemistry 52 51 9269-9274 2020-11-23T08:58:29Z 2020-11-23T08:58:29Z 2013 Article Bell, N.M, L'Hernault, A, Murat, P, Richards, J.E, Lever, A.M.L, Balasubramanian, S (2013). Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle. Biochemistry 52 (51) : 9269-9274. ScholarBank@NUS Repository. https://doi.org/10.1021/bi401270d 0006-2960 https://scholarbank.nus.edu.sg/handle/10635/183903 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Chemical Society Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	Diseases Genes Life cycle Molecules Proteins Viruses H NMR spectroscopy Human immunodeficiency virus type-1 Inhibitory activity RNA-protein interactions Structural elements Structural proteins Therapeutic targets Viral replication RNA Gag protein structural protein virus protein virus RNA anti human immunodeficiency virus agent molecular library NSC-260594 quinoline derivative ribonucleoprotein Schiff base spliced leader RNA virus RNA anti human immunodeficiency virus agent Gag protein NSC 260594 ribonucleoprotein spliced leader RNA 5' untranslated region article controlled study human human cell Human immunodeficiency virus 1 in vitro study life cycle stage molecule nonhuman priority journal protein expression protein RNA binding proton nuclear magnetic resonance virus genome virus infectivity virus particle virus replication antagonists and inhibitors binding site cell survival chemical structure chemistry conformation DNA denaturation drug effects drug screening HEK293 cell line HeLa cell line HIV Infections Human immunodeficiency virus 1 metabolism molecular library molecularly targeted therapy osmolarity physiology cell strain HEK293 drug antagonism drug effect HeLa cell Human immunodeficiency virus infection virus replication Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV Infections HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV Infections HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication
spellingShingle	Diseases Genes Life cycle Molecules Proteins Viruses H NMR spectroscopy Human immunodeficiency virus type-1 Inhibitory activity RNA-protein interactions Structural elements Structural proteins Therapeutic targets Viral replication RNA Gag protein structural protein virus protein virus RNA anti human immunodeficiency virus agent molecular library NSC-260594 quinoline derivative ribonucleoprotein Schiff base spliced leader RNA virus RNA anti human immunodeficiency virus agent Gag protein NSC 260594 ribonucleoprotein spliced leader RNA 5' untranslated region article controlled study human human cell Human immunodeficiency virus 1 in vitro study life cycle stage molecule nonhuman priority journal protein expression protein RNA binding proton nuclear magnetic resonance virus genome virus infectivity virus particle virus replication antagonists and inhibitors binding site cell survival chemical structure chemistry conformation DNA denaturation drug effects drug screening HEK293 cell line HeLa cell line HIV Infections Human immunodeficiency virus 1 metabolism molecular library molecularly targeted therapy osmolarity physiology cell strain HEK293 drug antagonism drug effect HeLa cell Human immunodeficiency virus infection virus replication Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV Infections HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication Anti-HIV Agents Binding Sites Cell Survival Drug Evaluation, Preclinical gag Gene Products, Human Immunodeficiency Virus HEK293 Cells HeLa Cells HIV Infections HIV-1 Humans Models, Molecular Molecular Targeted Therapy Nucleic Acid Conformation Nucleic Acid Denaturation Osmolar Concentration Quinolinium Compounds Ribonucleoproteins RNA, Spliced Leader RNA, Viral Schiff Bases Small Molecule Libraries Virus Replication Bell, N.M L'Hernault, A Murat, P Richards, J.E Lever, A.M.L Balasubramanian, S Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
description	10.1021/bi401270d
author2	MEDICINE
author_facet	MEDICINE Bell, N.M L'Hernault, A Murat, P Richards, J.E Lever, A.M.L Balasubramanian, S
format	Article
author	Bell, N.M L'Hernault, A Murat, P Richards, J.E Lever, A.M.L Balasubramanian, S
author_sort	Bell, N.M
title	Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
title_short	Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
title_full	Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
title_fullStr	Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
title_full_unstemmed	Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
title_sort	targeting rna-protein interactions within the human immunodeficiency virus type 1 lifecycle
publisher	American Chemical Society
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183903
_version_	1821220318392352768

Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle

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