Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

• Main Authors: Prutsch, N, Gurnhofer, E, Suske, T, Liang, HC, Schlederer, M, Roos, S, Wu, LC, Simonitsch-Klupp, I, Alvarez-Hernandez, A, Kornauth, C, Leone, DA, Svinka, J, Eferl, R, Limberger, T, Aufinger, A, Shirsath, N, Wolf, P, Hielscher, T, Aberger, F, Schmoellerl, J, Stoiber, D, Strobl, B, Jager, U, Staber, PB, Grebien, F, Moriggl, R, Muller, M, Inghirami, GG, Sanda, T, Look, AT, Turner, SD, Kenner, L, Merkel, O
• Other Authors: MEDICINE
• Format: Article
• Published: Springer Science and Business Media LLC 2021
• Subjects: Anaplastic Lymphoma Kinase; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large-Cell, Anaplastic; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; STAT1 Transcription Factor; STAT3 Transcription Factor; Signal Transduction; TYK2 Kinase; Translocation, Genetic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/205904
• Institution: National University of Singapore

10.1038/s41375-018-0239-1