An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

10.1093/hmg/ddw223

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Main Authors: Wyszynski, Asaf, Hong, Chi-Chen, Lam, Kristin, Michailidou, Kyriaki, Lytle, Christian, Yao, Song, Zhang, Yali, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Hopper, John L, Southey, Melissa C, Schmidt, Marjanka K, Broeks, Annegien, Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A, Beckmann, Matthias W, Peto, Julian, dos-Santos-Silva, Isabel, Sawyer, Elinor J, Tomlinson, Ian, Burwinkel, Barbara, Marme, Frederik, Guenel, Pascal, Truong, Therese, Bojesen, Stig E, Nordestgaard, Borge G, Gonzalez-Neira, Anna, Benitez, Javier, Neuhausen, Susan L, Brenner, Hermann, Dieffenbach, Aida Karina, Meindl, Alfons, Schmutzler, Rita K, Brauch, Hiltrud, Nevanlinna, Heli, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Doerk, Thilo, Bogdanova, Natalia V, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Wu, Anna H, Van den Berg, David, Lambrechts, Diether, Wildiers, Hans, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Peterlongo, Paolo, Couch, Fergus J, Olson, Janet E, Giles, Graham G, Milne, Roger L, Haiman, Christopher A, Henderson, Brian E, Dumont, Martine, Teo, Soo Hwang, Wong, Tien Y, Kristensen, Vessela, Zheng, Wei, Long, Jirong, Winqvist, Robert, Pylkas, Katri, Andrulis, Irene L, Knight, Julia A, Devilee, Peter, Seynaeve, Caroline, Garcia-Closas, Montserrat, Figueroa, Jonine, Klevebring, Daniel, Czene, Kamila, Hooning, Maartje J, van den Ouweland, Ans MW, Darabi, Hatef, Shu, Xiao-Ou, Gao, Yu-Tang, Cox, Angela, Blot, William, Signorello, Lisa B, Shah, Mitul, Kang, Daehee, Choi, Ji-Yeob, Hartman, Mikael, Miao, Hui, Hamann, Ute, Jakubowska, Anna, Lubinski, Jan, Sangrajrang, Suleeporn, McKay, James, Toland, Amanda E, Yannoukakos, Drakoulis, Shen, Chen-Yang, Wu, Pei-Ei, Swerdlow, Anthony, Orr, Nick, Simard, Jacques, Pharoah, Paul DP, Dunning, Alison M, Chenevix-Trench, Georgia, Hall, Per, Bandera, Elisa, Amos, Chris, Ambrosone, Christine, Easton, Douglas F, Cole, Michael D
Other Authors: SURGERY
Format: Article
Language:English
Published: OXFORD UNIV PRESS 2021
Subjects:
Online Access:https://scholarbank.nus.edu.sg/handle/10635/209216
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Institution: National University of Singapore
Language: English
id sg-nus-scholar.10635-209216
record_format dspace
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
language English
topic Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Genetics & Heredity
GENOME-WIDE ASSOCIATION
GENOTYPE IMPUTATION
GROWTH
SUSCEPTIBILITY
ACTIVATION
INVOLUTION
MUTATION
CELLS
spellingShingle Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Genetics & Heredity
GENOME-WIDE ASSOCIATION
GENOTYPE IMPUTATION
GROWTH
SUSCEPTIBILITY
ACTIVATION
INVOLUTION
MUTATION
CELLS
Wyszynski, Asaf
Hong, Chi-Chen
Lam, Kristin
Michailidou, Kyriaki
Lytle, Christian
Yao, Song
Zhang, Yali
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Hopper, John L
Southey, Melissa C
Schmidt, Marjanka K
Broeks, Annegien
Muir, Kenneth
Lophatananon, Artitaya
Fasching, Peter A
Beckmann, Matthias W
Peto, Julian
dos-Santos-Silva, Isabel
Sawyer, Elinor J
Tomlinson, Ian
Burwinkel, Barbara
Marme, Frederik
Guenel, Pascal
Truong, Therese
Bojesen, Stig E
Nordestgaard, Borge G
Gonzalez-Neira, Anna
Benitez, Javier
Neuhausen, Susan L
Brenner, Hermann
Dieffenbach, Aida Karina
Meindl, Alfons
Schmutzler, Rita K
Brauch, Hiltrud
Nevanlinna, Heli
Khan, Sofia
Matsuo, Keitaro
Ito, Hidemi
Doerk, Thilo
Bogdanova, Natalia V
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Wu, Anna H
Van den Berg, David
Lambrechts, Diether
Wildiers, Hans
Chang-Claude, Jenny
Rudolph, Anja
Radice, Paolo
Peterlongo, Paolo
Couch, Fergus J
Olson, Janet E
Giles, Graham G
Milne, Roger L
Haiman, Christopher A
Henderson, Brian E
Dumont, Martine
Teo, Soo Hwang
Wong, Tien Y
Kristensen, Vessela
Zheng, Wei
Long, Jirong
Winqvist, Robert
Pylkas, Katri
Andrulis, Irene L
Knight, Julia A
Devilee, Peter
Seynaeve, Caroline
Garcia-Closas, Montserrat
Figueroa, Jonine
Klevebring, Daniel
Czene, Kamila
Hooning, Maartje J
van den Ouweland, Ans MW
Darabi, Hatef
Shu, Xiao-Ou
Gao, Yu-Tang
Cox, Angela
Blot, William
Signorello, Lisa B
Shah, Mitul
Kang, Daehee
Choi, Ji-Yeob
Hartman, Mikael
Miao, Hui
Hamann, Ute
Jakubowska, Anna
Lubinski, Jan
Sangrajrang, Suleeporn
McKay, James
Toland, Amanda E
Yannoukakos, Drakoulis
Shen, Chen-Yang
Wu, Pei-Ei
Swerdlow, Anthony
Orr, Nick
Simard, Jacques
Pharoah, Paul DP
Dunning, Alison M
Chenevix-Trench, Georgia
Hall, Per
Bandera, Elisa
Amos, Chris
Ambrosone, Christine
Easton, Douglas F
Cole, Michael D
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
description 10.1093/hmg/ddw223
author2 SURGERY
author_facet SURGERY
Wyszynski, Asaf
Hong, Chi-Chen
Lam, Kristin
Michailidou, Kyriaki
Lytle, Christian
Yao, Song
Zhang, Yali
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Hopper, John L
Southey, Melissa C
Schmidt, Marjanka K
Broeks, Annegien
Muir, Kenneth
Lophatananon, Artitaya
Fasching, Peter A
Beckmann, Matthias W
Peto, Julian
dos-Santos-Silva, Isabel
Sawyer, Elinor J
Tomlinson, Ian
Burwinkel, Barbara
Marme, Frederik
Guenel, Pascal
Truong, Therese
Bojesen, Stig E
Nordestgaard, Borge G
Gonzalez-Neira, Anna
Benitez, Javier
Neuhausen, Susan L
Brenner, Hermann
Dieffenbach, Aida Karina
Meindl, Alfons
Schmutzler, Rita K
Brauch, Hiltrud
Nevanlinna, Heli
Khan, Sofia
Matsuo, Keitaro
Ito, Hidemi
Doerk, Thilo
Bogdanova, Natalia V
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Wu, Anna H
Van den Berg, David
Lambrechts, Diether
Wildiers, Hans
Chang-Claude, Jenny
Rudolph, Anja
Radice, Paolo
Peterlongo, Paolo
Couch, Fergus J
Olson, Janet E
Giles, Graham G
Milne, Roger L
Haiman, Christopher A
Henderson, Brian E
Dumont, Martine
Teo, Soo Hwang
Wong, Tien Y
Kristensen, Vessela
Zheng, Wei
Long, Jirong
Winqvist, Robert
Pylkas, Katri
Andrulis, Irene L
Knight, Julia A
Devilee, Peter
Seynaeve, Caroline
Garcia-Closas, Montserrat
Figueroa, Jonine
Klevebring, Daniel
Czene, Kamila
Hooning, Maartje J
van den Ouweland, Ans MW
Darabi, Hatef
Shu, Xiao-Ou
Gao, Yu-Tang
Cox, Angela
Blot, William
Signorello, Lisa B
Shah, Mitul
Kang, Daehee
Choi, Ji-Yeob
Hartman, Mikael
Miao, Hui
Hamann, Ute
Jakubowska, Anna
Lubinski, Jan
Sangrajrang, Suleeporn
McKay, James
Toland, Amanda E
Yannoukakos, Drakoulis
Shen, Chen-Yang
Wu, Pei-Ei
Swerdlow, Anthony
Orr, Nick
Simard, Jacques
Pharoah, Paul DP
Dunning, Alison M
Chenevix-Trench, Georgia
Hall, Per
Bandera, Elisa
Amos, Chris
Ambrosone, Christine
Easton, Douglas F
Cole, Michael D
format Article
author Wyszynski, Asaf
Hong, Chi-Chen
Lam, Kristin
Michailidou, Kyriaki
Lytle, Christian
Yao, Song
Zhang, Yali
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Hopper, John L
Southey, Melissa C
Schmidt, Marjanka K
Broeks, Annegien
Muir, Kenneth
Lophatananon, Artitaya
Fasching, Peter A
Beckmann, Matthias W
Peto, Julian
dos-Santos-Silva, Isabel
Sawyer, Elinor J
Tomlinson, Ian
Burwinkel, Barbara
Marme, Frederik
Guenel, Pascal
Truong, Therese
Bojesen, Stig E
Nordestgaard, Borge G
Gonzalez-Neira, Anna
Benitez, Javier
Neuhausen, Susan L
Brenner, Hermann
Dieffenbach, Aida Karina
Meindl, Alfons
Schmutzler, Rita K
Brauch, Hiltrud
Nevanlinna, Heli
Khan, Sofia
Matsuo, Keitaro
Ito, Hidemi
Doerk, Thilo
Bogdanova, Natalia V
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Wu, Anna H
Van den Berg, David
Lambrechts, Diether
Wildiers, Hans
Chang-Claude, Jenny
Rudolph, Anja
Radice, Paolo
Peterlongo, Paolo
Couch, Fergus J
Olson, Janet E
Giles, Graham G
Milne, Roger L
Haiman, Christopher A
Henderson, Brian E
Dumont, Martine
Teo, Soo Hwang
Wong, Tien Y
Kristensen, Vessela
Zheng, Wei
Long, Jirong
Winqvist, Robert
Pylkas, Katri
Andrulis, Irene L
Knight, Julia A
Devilee, Peter
Seynaeve, Caroline
Garcia-Closas, Montserrat
Figueroa, Jonine
Klevebring, Daniel
Czene, Kamila
Hooning, Maartje J
van den Ouweland, Ans MW
Darabi, Hatef
Shu, Xiao-Ou
Gao, Yu-Tang
Cox, Angela
Blot, William
Signorello, Lisa B
Shah, Mitul
Kang, Daehee
Choi, Ji-Yeob
Hartman, Mikael
Miao, Hui
Hamann, Ute
Jakubowska, Anna
Lubinski, Jan
Sangrajrang, Suleeporn
McKay, James
Toland, Amanda E
Yannoukakos, Drakoulis
Shen, Chen-Yang
Wu, Pei-Ei
Swerdlow, Anthony
Orr, Nick
Simard, Jacques
Pharoah, Paul DP
Dunning, Alison M
Chenevix-Trench, Georgia
Hall, Per
Bandera, Elisa
Amos, Chris
Ambrosone, Christine
Easton, Douglas F
Cole, Michael D
author_sort Wyszynski, Asaf
title An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
title_short An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
title_full An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
title_fullStr An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
title_full_unstemmed An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
title_sort intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating igfbp5 expression
publisher OXFORD UNIV PRESS
publishDate 2021
url https://scholarbank.nus.edu.sg/handle/10635/209216
_version_ 1800915166805622784
spelling sg-nus-scholar.10635-2092162024-04-25T02:38:00Z An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression Wyszynski, Asaf Hong, Chi-Chen Lam, Kristin Michailidou, Kyriaki Lytle, Christian Yao, Song Zhang, Yali Bolla, Manjeet K Wang, Qin Dennis, Joe Hopper, John L Southey, Melissa C Schmidt, Marjanka K Broeks, Annegien Muir, Kenneth Lophatananon, Artitaya Fasching, Peter A Beckmann, Matthias W Peto, Julian dos-Santos-Silva, Isabel Sawyer, Elinor J Tomlinson, Ian Burwinkel, Barbara Marme, Frederik Guenel, Pascal Truong, Therese Bojesen, Stig E Nordestgaard, Borge G Gonzalez-Neira, Anna Benitez, Javier Neuhausen, Susan L Brenner, Hermann Dieffenbach, Aida Karina Meindl, Alfons Schmutzler, Rita K Brauch, Hiltrud Nevanlinna, Heli Khan, Sofia Matsuo, Keitaro Ito, Hidemi Doerk, Thilo Bogdanova, Natalia V Lindblom, Annika Margolin, Sara Mannermaa, Arto Kosma, Veli-Matti Wu, Anna H Van den Berg, David Lambrechts, Diether Wildiers, Hans Chang-Claude, Jenny Rudolph, Anja Radice, Paolo Peterlongo, Paolo Couch, Fergus J Olson, Janet E Giles, Graham G Milne, Roger L Haiman, Christopher A Henderson, Brian E Dumont, Martine Teo, Soo Hwang Wong, Tien Y Kristensen, Vessela Zheng, Wei Long, Jirong Winqvist, Robert Pylkas, Katri Andrulis, Irene L Knight, Julia A Devilee, Peter Seynaeve, Caroline Garcia-Closas, Montserrat Figueroa, Jonine Klevebring, Daniel Czene, Kamila Hooning, Maartje J van den Ouweland, Ans MW Darabi, Hatef Shu, Xiao-Ou Gao, Yu-Tang Cox, Angela Blot, William Signorello, Lisa B Shah, Mitul Kang, Daehee Choi, Ji-Yeob Hartman, Mikael Miao, Hui Hamann, Ute Jakubowska, Anna Lubinski, Jan Sangrajrang, Suleeporn McKay, James Toland, Amanda E Yannoukakos, Drakoulis Shen, Chen-Yang Wu, Pei-Ei Swerdlow, Anthony Orr, Nick Simard, Jacques Pharoah, Paul DP Dunning, Alison M Chenevix-Trench, Georgia Hall, Per Bandera, Elisa Amos, Chris Ambrosone, Christine Easton, Douglas F Cole, Michael D SURGERY Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology Genetics & Heredity GENOME-WIDE ASSOCIATION GENOTYPE IMPUTATION GROWTH SUSCEPTIBILITY ACTIVATION INVOLUTION MUTATION CELLS 10.1093/hmg/ddw223 HUMAN MOLECULAR GENETICS 25 17 3863-3876 2021-12-02T06:05:59Z 2021-12-02T06:05:59Z 2016-09-01 2021-12-01T15:48:41Z Article Wyszynski, Asaf, Hong, Chi-Chen, Lam, Kristin, Michailidou, Kyriaki, Lytle, Christian, Yao, Song, Zhang, Yali, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Hopper, John L, Southey, Melissa C, Schmidt, Marjanka K, Broeks, Annegien, Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A, Beckmann, Matthias W, Peto, Julian, dos-Santos-Silva, Isabel, Sawyer, Elinor J, Tomlinson, Ian, Burwinkel, Barbara, Marme, Frederik, Guenel, Pascal, Truong, Therese, Bojesen, Stig E, Nordestgaard, Borge G, Gonzalez-Neira, Anna, Benitez, Javier, Neuhausen, Susan L, Brenner, Hermann, Dieffenbach, Aida Karina, Meindl, Alfons, Schmutzler, Rita K, Brauch, Hiltrud, Nevanlinna, Heli, Khan, Sofia, Matsuo, Keitaro, Ito, Hidemi, Doerk, Thilo, Bogdanova, Natalia V, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Wu, Anna H, Van den Berg, David, Lambrechts, Diether, Wildiers, Hans, Chang-Claude, Jenny, Rudolph, Anja, Radice, Paolo, Peterlongo, Paolo, Couch, Fergus J, Olson, Janet E, Giles, Graham G, Milne, Roger L, Haiman, Christopher A, Henderson, Brian E, Dumont, Martine, Teo, Soo Hwang, Wong, Tien Y, Kristensen, Vessela, Zheng, Wei, Long, Jirong, Winqvist, Robert, Pylkas, Katri, Andrulis, Irene L, Knight, Julia A, Devilee, Peter, Seynaeve, Caroline, Garcia-Closas, Montserrat, Figueroa, Jonine, Klevebring, Daniel, Czene, Kamila, Hooning, Maartje J, van den Ouweland, Ans MW, Darabi, Hatef, Shu, Xiao-Ou, Gao, Yu-Tang, Cox, Angela, Blot, William, Signorello, Lisa B, Shah, Mitul, Kang, Daehee, Choi, Ji-Yeob, Hartman, Mikael, Miao, Hui, Hamann, Ute, Jakubowska, Anna, Lubinski, Jan, Sangrajrang, Suleeporn, McKay, James, Toland, Amanda E, Yannoukakos, Drakoulis, Shen, Chen-Yang, Wu, Pei-Ei, Swerdlow, Anthony, Orr, Nick, Simard, Jacques, Pharoah, Paul DP, Dunning, Alison M, Chenevix-Trench, Georgia, Hall, Per, Bandera, Elisa, Amos, Chris, Ambrosone, Christine, Easton, Douglas F, Cole, Michael D (2016-09-01). An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. HUMAN MOLECULAR GENETICS 25 (17) : 3863-3876. ScholarBank@NUS Repository. https://doi.org/10.1093/hmg/ddw223 09646906 14602083 https://scholarbank.nus.edu.sg/handle/10635/209216 en OXFORD UNIV PRESS Elements