BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer

CANCER RESEARCH

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Main Authors: Shimelis, Hermela, Mesman, Romy LS, Von Nicolai, Catharina, Ehlen, Asa, Guidugli, Lucia, Martin, Charlotte, Calleja, Fabienne MGR, Meeks, Huong, Hallberg, Emily, Hinton, Jamie, Lilyquist, Jenna, Hu, Chunling, Aalfs, Cora M, Aittomaki, Kristiina, Andrulis, Irene, Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W, Benitez, Javier, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Broeks, Annegien, Brouwers, Barbara, Bruning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cheng, Ching-Yu, Choi, Ji-Yeob, Collee, J Margriet, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Dennis, Joe, Dork, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Garcia-Closas, Montserrat, Giles, Graham G, Glendon, Gord, Guenel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hartman, Mikael, Hogervorst, Frans B, Hollestelle, Antoinette, Hopper, John L, Ito, Hidemi, Jakubowska, Anna, Kang, Daehee, Kosma, Veli-Matti, Kristensen, Vessela, Lai, Kah-Nyin, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Machackova, Eva, Mannermaa, Arto, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro, Miao, Hui, Michailidou, Kyriaki, Milne, Roger L, Muir, Kenneth, Neuhausen, Susan L, Nevanlinna, Heli, Olson, Janet E, Olswold, Curtis, Oosterwijk, Jan JC, Osorio, Ana, Peterlongo, Paolo, Peto, Julian, Pharoah, Pauld DP, Pylkas, Katri, Radice, Paolo, Rashid, Muhammad Usman, Rhenius, Valerie, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J, Schmidt, Marjanka K, Schoemaker, Minouk J, Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shrubsole, Martha, Shu, Xiao-Ou, Slager, Susan, Southey, Melissa C, Stram, Daniel O, Swerdlow, Anthony, Teo, Soo H, Tomlinson, Ian, Torres, Diana, Truong, Therese, van Asperen, Christi J, van der Kolk, Lizet E, Wang, Qin, Winqvist, Robert, Wu, Anna H, Yu, Jyh-Cherng, Zheng, Wei, Zheng, Ying, Leary, Jennifer, Walker, Logan, Foretova, Lenka, Fostira, Florentia, Claes, Kathleen BM, Varesco, Liliana, Moghadasi, Setareh, Easton, Douglas F, Spurdle, Amanda, Devilee, Peter, Vrieling, Harry, Monteiro, Alvaro NA, Goldgar, David E, Carreira, Aura, Vreeswijk, Maaike PG, Couch, Fergus J
Other Authors: SURGERY
Format: Article
Language:English
Published: AMER ASSOC CANCER RESEARCH 2021
Subjects:
Online Access:https://scholarbank.nus.edu.sg/handle/10635/209296
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Institution: National University of Singapore
Language: English
id sg-nus-scholar.10635-209296
record_format dspace
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
language English
topic Science & Technology
Life Sciences & Biomedicine
Oncology
UNKNOWN CLINICAL-SIGNIFICANCE
CELL-BASED ASSAY
UNCERTAIN SIGNIFICANCE
OVARIAN-CANCER
UNCLASSIFIED VARIANTS
SEQUENCE VARIANTS
DNA-BINDING
FUNCTIONAL-EVALUATION
GENES
CLASSIFICATION
spellingShingle Science & Technology
Life Sciences & Biomedicine
Oncology
UNKNOWN CLINICAL-SIGNIFICANCE
CELL-BASED ASSAY
UNCERTAIN SIGNIFICANCE
OVARIAN-CANCER
UNCLASSIFIED VARIANTS
SEQUENCE VARIANTS
DNA-BINDING
FUNCTIONAL-EVALUATION
GENES
CLASSIFICATION
Shimelis, Hermela
Mesman, Romy LS
Von Nicolai, Catharina
Ehlen, Asa
Guidugli, Lucia
Martin, Charlotte
Calleja, Fabienne MGR
Meeks, Huong
Hallberg, Emily
Hinton, Jamie
Lilyquist, Jenna
Hu, Chunling
Aalfs, Cora M
Aittomaki, Kristiina
Andrulis, Irene
Anton-Culver, Hoda
Arndt, Volker
Beckmann, Matthias W
Benitez, Javier
Bogdanova, Natalia V
Bojesen, Stig E
Bolla, Manjeet K
Borresen-Dale, Anne-Lise
Brauch, Hiltrud
Brennan, Paul
Brenner, Hermann
Broeks, Annegien
Brouwers, Barbara
Bruning, Thomas
Burwinkel, Barbara
Chang-Claude, Jenny
Chenevix-Trench, Georgia
Cheng, Ching-Yu
Choi, Ji-Yeob
Collee, J Margriet
Cox, Angela
Cross, Simon S
Czene, Kamila
Darabi, Hatef
Dennis, Joe
Dork, Thilo
dos-Santos-Silva, Isabel
Dunning, Alison M
Fasching, Peter A
Figueroa, Jonine
Flyger, Henrik
Garcia-Closas, Montserrat
Giles, Graham G
Glendon, Gord
Guenel, Pascal
Haiman, Christopher A
Hall, Per
Hamann, Ute
Hartman, Mikael
Hogervorst, Frans B
Hollestelle, Antoinette
Hopper, John L
Ito, Hidemi
Jakubowska, Anna
Kang, Daehee
Kosma, Veli-Matti
Kristensen, Vessela
Lai, Kah-Nyin
Lambrechts, Diether
Le Marchand, Loic
Li, Jingmei
Lindblom, Annika
Lophatananon, Artitaya
Lubinski, Jan
Machackova, Eva
Mannermaa, Arto
Margolin, Sara
Marme, Frederik
Matsuo, Keitaro
Miao, Hui
Michailidou, Kyriaki
Milne, Roger L
Muir, Kenneth
Neuhausen, Susan L
Nevanlinna, Heli
Olson, Janet E
Olswold, Curtis
Oosterwijk, Jan JC
Osorio, Ana
Peterlongo, Paolo
Peto, Julian
Pharoah, Pauld DP
Pylkas, Katri
Radice, Paolo
Rashid, Muhammad Usman
Rhenius, Valerie
Rudolph, Anja
Sangrajrang, Suleeporn
Sawyer, Elinor J
Schmidt, Marjanka K
Schoemaker, Minouk J
Seynaeve, Caroline
Shah, Mitul
Shen, Chen-Yang
Shrubsole, Martha
Shu, Xiao-Ou
Slager, Susan
Southey, Melissa C
Stram, Daniel O
Swerdlow, Anthony
Teo, Soo H
Tomlinson, Ian
Torres, Diana
Truong, Therese
van Asperen, Christi J
van der Kolk, Lizet E
Wang, Qin
Winqvist, Robert
Wu, Anna H
Yu, Jyh-Cherng
Zheng, Wei
Zheng, Ying
Leary, Jennifer
Walker, Logan
Foretova, Lenka
Fostira, Florentia
Claes, Kathleen BM
Varesco, Liliana
Moghadasi, Setareh
Easton, Douglas F
Spurdle, Amanda
Devilee, Peter
Vrieling, Harry
Monteiro, Alvaro NA
Goldgar, David E
Carreira, Aura
Vreeswijk, Maaike PG
Couch, Fergus J
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
description CANCER RESEARCH
author2 SURGERY
author_facet SURGERY
Shimelis, Hermela
Mesman, Romy LS
Von Nicolai, Catharina
Ehlen, Asa
Guidugli, Lucia
Martin, Charlotte
Calleja, Fabienne MGR
Meeks, Huong
Hallberg, Emily
Hinton, Jamie
Lilyquist, Jenna
Hu, Chunling
Aalfs, Cora M
Aittomaki, Kristiina
Andrulis, Irene
Anton-Culver, Hoda
Arndt, Volker
Beckmann, Matthias W
Benitez, Javier
Bogdanova, Natalia V
Bojesen, Stig E
Bolla, Manjeet K
Borresen-Dale, Anne-Lise
Brauch, Hiltrud
Brennan, Paul
Brenner, Hermann
Broeks, Annegien
Brouwers, Barbara
Bruning, Thomas
Burwinkel, Barbara
Chang-Claude, Jenny
Chenevix-Trench, Georgia
Cheng, Ching-Yu
Choi, Ji-Yeob
Collee, J Margriet
Cox, Angela
Cross, Simon S
Czene, Kamila
Darabi, Hatef
Dennis, Joe
Dork, Thilo
dos-Santos-Silva, Isabel
Dunning, Alison M
Fasching, Peter A
Figueroa, Jonine
Flyger, Henrik
Garcia-Closas, Montserrat
Giles, Graham G
Glendon, Gord
Guenel, Pascal
Haiman, Christopher A
Hall, Per
Hamann, Ute
Hartman, Mikael
Hogervorst, Frans B
Hollestelle, Antoinette
Hopper, John L
Ito, Hidemi
Jakubowska, Anna
Kang, Daehee
Kosma, Veli-Matti
Kristensen, Vessela
Lai, Kah-Nyin
Lambrechts, Diether
Le Marchand, Loic
Li, Jingmei
Lindblom, Annika
Lophatananon, Artitaya
Lubinski, Jan
Machackova, Eva
Mannermaa, Arto
Margolin, Sara
Marme, Frederik
Matsuo, Keitaro
Miao, Hui
Michailidou, Kyriaki
Milne, Roger L
Muir, Kenneth
Neuhausen, Susan L
Nevanlinna, Heli
Olson, Janet E
Olswold, Curtis
Oosterwijk, Jan JC
Osorio, Ana
Peterlongo, Paolo
Peto, Julian
Pharoah, Pauld DP
Pylkas, Katri
Radice, Paolo
Rashid, Muhammad Usman
Rhenius, Valerie
Rudolph, Anja
Sangrajrang, Suleeporn
Sawyer, Elinor J
Schmidt, Marjanka K
Schoemaker, Minouk J
Seynaeve, Caroline
Shah, Mitul
Shen, Chen-Yang
Shrubsole, Martha
Shu, Xiao-Ou
Slager, Susan
Southey, Melissa C
Stram, Daniel O
Swerdlow, Anthony
Teo, Soo H
Tomlinson, Ian
Torres, Diana
Truong, Therese
van Asperen, Christi J
van der Kolk, Lizet E
Wang, Qin
Winqvist, Robert
Wu, Anna H
Yu, Jyh-Cherng
Zheng, Wei
Zheng, Ying
Leary, Jennifer
Walker, Logan
Foretova, Lenka
Fostira, Florentia
Claes, Kathleen BM
Varesco, Liliana
Moghadasi, Setareh
Easton, Douglas F
Spurdle, Amanda
Devilee, Peter
Vrieling, Harry
Monteiro, Alvaro NA
Goldgar, David E
Carreira, Aura
Vreeswijk, Maaike PG
Couch, Fergus J
format Article
author Shimelis, Hermela
Mesman, Romy LS
Von Nicolai, Catharina
Ehlen, Asa
Guidugli, Lucia
Martin, Charlotte
Calleja, Fabienne MGR
Meeks, Huong
Hallberg, Emily
Hinton, Jamie
Lilyquist, Jenna
Hu, Chunling
Aalfs, Cora M
Aittomaki, Kristiina
Andrulis, Irene
Anton-Culver, Hoda
Arndt, Volker
Beckmann, Matthias W
Benitez, Javier
Bogdanova, Natalia V
Bojesen, Stig E
Bolla, Manjeet K
Borresen-Dale, Anne-Lise
Brauch, Hiltrud
Brennan, Paul
Brenner, Hermann
Broeks, Annegien
Brouwers, Barbara
Bruning, Thomas
Burwinkel, Barbara
Chang-Claude, Jenny
Chenevix-Trench, Georgia
Cheng, Ching-Yu
Choi, Ji-Yeob
Collee, J Margriet
Cox, Angela
Cross, Simon S
Czene, Kamila
Darabi, Hatef
Dennis, Joe
Dork, Thilo
dos-Santos-Silva, Isabel
Dunning, Alison M
Fasching, Peter A
Figueroa, Jonine
Flyger, Henrik
Garcia-Closas, Montserrat
Giles, Graham G
Glendon, Gord
Guenel, Pascal
Haiman, Christopher A
Hall, Per
Hamann, Ute
Hartman, Mikael
Hogervorst, Frans B
Hollestelle, Antoinette
Hopper, John L
Ito, Hidemi
Jakubowska, Anna
Kang, Daehee
Kosma, Veli-Matti
Kristensen, Vessela
Lai, Kah-Nyin
Lambrechts, Diether
Le Marchand, Loic
Li, Jingmei
Lindblom, Annika
Lophatananon, Artitaya
Lubinski, Jan
Machackova, Eva
Mannermaa, Arto
Margolin, Sara
Marme, Frederik
Matsuo, Keitaro
Miao, Hui
Michailidou, Kyriaki
Milne, Roger L
Muir, Kenneth
Neuhausen, Susan L
Nevanlinna, Heli
Olson, Janet E
Olswold, Curtis
Oosterwijk, Jan JC
Osorio, Ana
Peterlongo, Paolo
Peto, Julian
Pharoah, Pauld DP
Pylkas, Katri
Radice, Paolo
Rashid, Muhammad Usman
Rhenius, Valerie
Rudolph, Anja
Sangrajrang, Suleeporn
Sawyer, Elinor J
Schmidt, Marjanka K
Schoemaker, Minouk J
Seynaeve, Caroline
Shah, Mitul
Shen, Chen-Yang
Shrubsole, Martha
Shu, Xiao-Ou
Slager, Susan
Southey, Melissa C
Stram, Daniel O
Swerdlow, Anthony
Teo, Soo H
Tomlinson, Ian
Torres, Diana
Truong, Therese
van Asperen, Christi J
van der Kolk, Lizet E
Wang, Qin
Winqvist, Robert
Wu, Anna H
Yu, Jyh-Cherng
Zheng, Wei
Zheng, Ying
Leary, Jennifer
Walker, Logan
Foretova, Lenka
Fostira, Florentia
Claes, Kathleen BM
Varesco, Liliana
Moghadasi, Setareh
Easton, Douglas F
Spurdle, Amanda
Devilee, Peter
Vrieling, Harry
Monteiro, Alvaro NA
Goldgar, David E
Carreira, Aura
Vreeswijk, Maaike PG
Couch, Fergus J
author_sort Shimelis, Hermela
title BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
title_short BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
title_full BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
title_fullStr BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
title_full_unstemmed BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
title_sort brca2 hypomorphic missense variants confer moderate risks of breast cancer
publisher AMER ASSOC CANCER RESEARCH
publishDate 2021
url https://scholarbank.nus.edu.sg/handle/10635/209296
_version_ 1800915167899287552
spelling sg-nus-scholar.10635-2092962024-04-25T02:38:56Z BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Shimelis, Hermela Mesman, Romy LS Von Nicolai, Catharina Ehlen, Asa Guidugli, Lucia Martin, Charlotte Calleja, Fabienne MGR Meeks, Huong Hallberg, Emily Hinton, Jamie Lilyquist, Jenna Hu, Chunling Aalfs, Cora M Aittomaki, Kristiina Andrulis, Irene Anton-Culver, Hoda Arndt, Volker Beckmann, Matthias W Benitez, Javier Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Borresen-Dale, Anne-Lise Brauch, Hiltrud Brennan, Paul Brenner, Hermann Broeks, Annegien Brouwers, Barbara Bruning, Thomas Burwinkel, Barbara Chang-Claude, Jenny Chenevix-Trench, Georgia Cheng, Ching-Yu Choi, Ji-Yeob Collee, J Margriet Cox, Angela Cross, Simon S Czene, Kamila Darabi, Hatef Dennis, Joe Dork, Thilo dos-Santos-Silva, Isabel Dunning, Alison M Fasching, Peter A Figueroa, Jonine Flyger, Henrik Garcia-Closas, Montserrat Giles, Graham G Glendon, Gord Guenel, Pascal Haiman, Christopher A Hall, Per Hamann, Ute Hartman, Mikael Hogervorst, Frans B Hollestelle, Antoinette Hopper, John L Ito, Hidemi Jakubowska, Anna Kang, Daehee Kosma, Veli-Matti Kristensen, Vessela Lai, Kah-Nyin Lambrechts, Diether Le Marchand, Loic Li, Jingmei Lindblom, Annika Lophatananon, Artitaya Lubinski, Jan Machackova, Eva Mannermaa, Arto Margolin, Sara Marme, Frederik Matsuo, Keitaro Miao, Hui Michailidou, Kyriaki Milne, Roger L Muir, Kenneth Neuhausen, Susan L Nevanlinna, Heli Olson, Janet E Olswold, Curtis Oosterwijk, Jan JC Osorio, Ana Peterlongo, Paolo Peto, Julian Pharoah, Pauld DP Pylkas, Katri Radice, Paolo Rashid, Muhammad Usman Rhenius, Valerie Rudolph, Anja Sangrajrang, Suleeporn Sawyer, Elinor J Schmidt, Marjanka K Schoemaker, Minouk J Seynaeve, Caroline Shah, Mitul Shen, Chen-Yang Shrubsole, Martha Shu, Xiao-Ou Slager, Susan Southey, Melissa C Stram, Daniel O Swerdlow, Anthony Teo, Soo H Tomlinson, Ian Torres, Diana Truong, Therese van Asperen, Christi J van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wu, Anna H Yu, Jyh-Cherng Zheng, Wei Zheng, Ying Leary, Jennifer Walker, Logan Foretova, Lenka Fostira, Florentia Claes, Kathleen BM Varesco, Liliana Moghadasi, Setareh Easton, Douglas F Spurdle, Amanda Devilee, Peter Vrieling, Harry Monteiro, Alvaro NA Goldgar, David E Carreira, Aura Vreeswijk, Maaike PG Couch, Fergus J SURGERY Science & Technology Life Sciences & Biomedicine Oncology UNKNOWN CLINICAL-SIGNIFICANCE CELL-BASED ASSAY UNCERTAIN SIGNIFICANCE OVARIAN-CANCER UNCLASSIFIED VARIANTS SEQUENCE VARIANTS DNA-BINDING FUNCTIONAL-EVALUATION GENES CLASSIFICATION CANCER RESEARCH 77 11 2789-2799 CNREA 2021-12-02T08:13:17Z 2021-12-02T08:13:17Z 2017-06-01 2021-12-01T16:53:28Z Article Shimelis, Hermela, Mesman, Romy LS, Von Nicolai, Catharina, Ehlen, Asa, Guidugli, Lucia, Martin, Charlotte, Calleja, Fabienne MGR, Meeks, Huong, Hallberg, Emily, Hinton, Jamie, Lilyquist, Jenna, Hu, Chunling, Aalfs, Cora M, Aittomaki, Kristiina, Andrulis, Irene, Anton-Culver, Hoda, Arndt, Volker, Beckmann, Matthias W, Benitez, Javier, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Borresen-Dale, Anne-Lise, Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Broeks, Annegien, Brouwers, Barbara, Bruning, Thomas, Burwinkel, Barbara, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Cheng, Ching-Yu, Choi, Ji-Yeob, Collee, J Margriet, Cox, Angela, Cross, Simon S, Czene, Kamila, Darabi, Hatef, Dennis, Joe, Dork, Thilo, dos-Santos-Silva, Isabel, Dunning, Alison M, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Garcia-Closas, Montserrat, Giles, Graham G, Glendon, Gord, Guenel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hartman, Mikael, Hogervorst, Frans B, Hollestelle, Antoinette, Hopper, John L, Ito, Hidemi, Jakubowska, Anna, Kang, Daehee, Kosma, Veli-Matti, Kristensen, Vessela, Lai, Kah-Nyin, Lambrechts, Diether, Le Marchand, Loic, Li, Jingmei, Lindblom, Annika, Lophatananon, Artitaya, Lubinski, Jan, Machackova, Eva, Mannermaa, Arto, Margolin, Sara, Marme, Frederik, Matsuo, Keitaro, Miao, Hui, Michailidou, Kyriaki, Milne, Roger L, Muir, Kenneth, Neuhausen, Susan L, Nevanlinna, Heli, Olson, Janet E, Olswold, Curtis, Oosterwijk, Jan JC, Osorio, Ana, Peterlongo, Paolo, Peto, Julian, Pharoah, Pauld DP, Pylkas, Katri, Radice, Paolo, Rashid, Muhammad Usman, Rhenius, Valerie, Rudolph, Anja, Sangrajrang, Suleeporn, Sawyer, Elinor J, Schmidt, Marjanka K, Schoemaker, Minouk J, Seynaeve, Caroline, Shah, Mitul, Shen, Chen-Yang, Shrubsole, Martha, Shu, Xiao-Ou, Slager, Susan, Southey, Melissa C, Stram, Daniel O, Swerdlow, Anthony, Teo, Soo H, Tomlinson, Ian, Torres, Diana, Truong, Therese, van Asperen, Christi J, van der Kolk, Lizet E, Wang, Qin, Winqvist, Robert, Wu, Anna H, Yu, Jyh-Cherng, Zheng, Wei, Zheng, Ying, Leary, Jennifer, Walker, Logan, Foretova, Lenka, Fostira, Florentia, Claes, Kathleen BM, Varesco, Liliana, Moghadasi, Setareh, Easton, Douglas F, Spurdle, Amanda, Devilee, Peter, Vrieling, Harry, Monteiro, Alvaro NA, Goldgar, David E, Carreira, Aura, Vreeswijk, Maaike PG, Couch, Fergus J (2017-06-01). BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer. CANCER RESEARCH 77 (11) : 2789-2799. ScholarBank@NUS Repository. 00085472 15387445 https://scholarbank.nus.edu.sg/handle/10635/209296 en AMER ASSOC CANCER RESEARCH Elements