Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome

• Main Authors: Hsieh, CY, Li, LH, Lam, Y, Fang, Z, Gan, CH, Rao, YK, Chiu, HW, Wong, WT, Ju, TC, Chen, FH, Chernikov, OV, Liu, ML, Hsu, CH, Hua, KF
• Other Authors: CHEMISTRY
• Format: Article
• Published: MDPI AG 2023
• Subjects: 4-hydroxy auxarconjugatin B; NLRP3 inflammasome; autophagy; gouty inflammation; mitochondria; Animals; Arthritis, Gouty; Autophagy; CARD Signaling Adaptor Proteins; Cell Line; Disease Models, Animal; Humans; Inflammasomes; Inflammation; Lipopolysaccharides; Lysosomes; Macrophages; Male; Mice, Inbred C57BL; Mitochondria; Models, Biological; NLR Family, Pyrin Domain-Containing 3 Protein; Organelle Biogenesis; Protein Multimerization; Pyrroles; Sirtuin 1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/242991
• Institution: National University of Singapore

10.3390/cells9020279