A simple new scoring system for predicting the mortality of severe acute pancreatitis: A retrospective clinical study

• Main Authors: WANG, Lei, ZENG, Yan-Bo, CHEN, Jia-Yun, LUO, Qian, WANG, Rowan, ZHANG, Ruijie, ZHENG, Zhichao, DONG, Yuan-Hang, ZOU, Wen-Bin, XIE, Xiaoqing, DU, Yi-Qi, LI, Zhao-Shen
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2020
• Subjects: disease severity; mortality; prognostic scoring system; severe acute pancreatitis; Medicine and Health Sciences; Operations and Supply Chain Management
• Online Access: https://ink.library.smu.edu.sg/lkcsb_research/6642; https://ink.library.smu.edu.sg/context/lkcsb_research/article/7641/viewcontent/Simple_new_scoring_system_predicting_pvoa.pdf
• Institution: Singapore Management University

It is critical to accurately identify patients with severe acute pancreatitis (SAP) in a timely manner. This study aimed to develop a new simplified AP scoring system based on data from Chinese population.We retrospectively analyzed a consecutive series of 585 patients diagnosed with SAP at the Changhai hospital between 2009 and 2017. The new Chinese simple scoring system (CSSS) was derived using logistic regression analysis and was validated in comparison to 4 existing systems using receiver operating characteristic curves.Six variables were selected for incorporation into CSSS, including serum creatinine, blood glucose, lactate dehydrogenase, heart rate, C-reactive protein, and extent of pancreatic necrosis. The new CSSS yields a maximum total score of 9 points. The cut-offs for predicting mortality and severity (discriminating moderately SAP from SAP) were set as 6 points and 4 points respectively. Compared with 4 existing scoring systems, the area under the receiver operating characteristic of CSSS for prediction of mortality was 0.838, similar to acute physiology and chronic health evaluation II (0.844) and higher than Ranson's score (0.702, P A new prognostic scoring system for SAP was derived and validated in a Chinese sample. This scoring system is a simple and accurate method for prediction of mortality.