Structural analysis of the hot spots in the binding between H1N1 HA and the 2DI antibody: Do mutations of H1N1 from 1918 to 2009 affect much on this binding?

• Main Authors: LIU, Qian, HOI, Steven C. H., SU, Chinh T. T., LI, Zhenhua, KWOH, Chee-Keong, WONG, Limsoon, LI, Jinyan
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2011
• Subjects: Bioinformatics; Computer Sciences; Databases and Information Systems
• Online Access: https://ink.library.smu.edu.sg/sis_research/2270; https://ink.library.smu.edu.sg/context/sis_research/article/3270/viewcontent/btr437.pdf
• Institution: Singapore Management University

Worldwide and substantial mortality caused by the 2009 H1N1 influenza A has stimulated a new surge of research on H1N1 viruses. An epitope conservation has been learned in the HA1 protein that allows antibodies to cross-neutralize both 1918 and 2009 H1N1. However, few works have thoroughly studied t...