Fusing Heterogeneous Data for Alzheimer's Disease Classification

• Main Authors: Pillai, P. S., Tze-Yun LEONG
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2015
• Subjects: Alzheimer's disease; Data fusion; Heterogeneous; Multimodal; Databases and Information Systems; Health Information Technology
• Online Access: https://ink.library.smu.edu.sg/sis_research/3019; https://ink.library.smu.edu.sg/context/sis_research/article/4019/viewcontent/Fusing_Heterogeneous_Data_for_Alzheimer_s_Disease_Classification.pdf
• Institution: Singapore Management University

In multi-view learning, multimodal representations of a real world object or situation are integrated to learn its overall picture. Feature sets from distinct data sources carry different, yet complementary, information which, if analysed together, usually yield better insights and more accurate results. Neuro-degenerative disorders such as dementia are characterized by changes in multiple biomarkers. This work combines the features from neuroimaging and cerebrospinal fluid studies to distinguish Alzheimer's disease patients from healthy subjects. We apply statistical data fusion techniques on 101 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We examine whether fusion of biomarkers helps to improve diagnostic accuracy and how the methods compare against each other for this problem. Our results indicate that multimodal data fusion improves classification accuracy.