Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips
Digital microfluidic biochips (DMFBs) have a significant stride in the applications of medicine and the biochemistry in recent years. DMFBs based on micro-electrode-dot-array (MEDA) architecture, as the next-generation DMFBs, aim to overcome drawbacks of conventional DMFBs, such as droplet size rest...
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sg-smu-ink.sis_research-97192024-04-04T07:42:08Z Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips DONG, Chen GUO, Xiaodong LIAN, Sihuang YAO, Yinan CHEN, Zhenyi YANG, Yang LIU, Zhanghui Digital microfluidic biochips (DMFBs) have a significant stride in the applications of medicine and the biochemistry in recent years. DMFBs based on micro-electrode-dot-array (MEDA) architecture, as the next-generation DMFBs, aim to overcome drawbacks of conventional DMFBs, such as droplet size restriction, low accuracy, and poor sensing ability. Since the potential market value of MEDA biochips is vast, it is of paramount importance to explore approaches to protect the intellectual property (IP) of MEDA biochips during the development process. In this paper, an IP authentication strategy based on the multi-PUF applied to MEDA biochips is presented, called bioMPUF, consisting of Delay PUF, Split PUF and Countermeasure. The bioMPUF strategy is designed to enhance the non-linearity between challenges and responses of PUFs, making the challenge–response pairs (CRPs) on the MEDA biochips are difficult to be anticipated, thus thwarting IP piracy attacks. Moreover, based on the easy degradation of MEDA biochip electrodes, a countermeasure is proposed to destroy the availability of piracy chips. Experimental results demonstrate the feasibility of the proposed bioMPUF strategy against the brute force attack and modeling attack. 2024-03-01T08:00:00Z text application/pdf https://ink.library.smu.edu.sg/sis_research/8716 info:doi/10.1016/j.jksuci.2024.101996 https://ink.library.smu.edu.sg/context/sis_research/article/9719/viewcontent/1_s2.0_S1319157824000855_pvoa_cc_nc_nd.pdf http://creativecommons.org/licenses/by-nc-nd/4.0/ Research Collection School Of Computing and Information Systems eng Institutional Knowledge at Singapore Management University Hardware security IP protection MEDA biochips Modeling attack Multi-PUF Information Security |
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Hardware security IP protection MEDA biochips Modeling attack Multi-PUF Information Security DONG, Chen GUO, Xiaodong LIAN, Sihuang YAO, Yinan CHEN, Zhenyi YANG, Yang LIU, Zhanghui Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips |
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Digital microfluidic biochips (DMFBs) have a significant stride in the applications of medicine and the biochemistry in recent years. DMFBs based on micro-electrode-dot-array (MEDA) architecture, as the next-generation DMFBs, aim to overcome drawbacks of conventional DMFBs, such as droplet size restriction, low accuracy, and poor sensing ability. Since the potential market value of MEDA biochips is vast, it is of paramount importance to explore approaches to protect the intellectual property (IP) of MEDA biochips during the development process. In this paper, an IP authentication strategy based on the multi-PUF applied to MEDA biochips is presented, called bioMPUF, consisting of Delay PUF, Split PUF and Countermeasure. The bioMPUF strategy is designed to enhance the non-linearity between challenges and responses of PUFs, making the challenge–response pairs (CRPs) on the MEDA biochips are difficult to be anticipated, thus thwarting IP piracy attacks. Moreover, based on the easy degradation of MEDA biochip electrodes, a countermeasure is proposed to destroy the availability of piracy chips. Experimental results demonstrate the feasibility of the proposed bioMPUF strategy against the brute force attack and modeling attack. |
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DONG, Chen GUO, Xiaodong LIAN, Sihuang YAO, Yinan CHEN, Zhenyi YANG, Yang LIU, Zhanghui |
author_facet |
DONG, Chen GUO, Xiaodong LIAN, Sihuang YAO, Yinan CHEN, Zhenyi YANG, Yang LIU, Zhanghui |
author_sort |
DONG, Chen |
title |
Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips |
title_short |
Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips |
title_full |
Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips |
title_fullStr |
Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips |
title_full_unstemmed |
Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochips |
title_sort |
harnessing the advances of meda to optimize multi-puf for enhancing ip security of biochips |
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Institutional Knowledge at Singapore Management University |
publishDate |
2024 |
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https://ink.library.smu.edu.sg/sis_research/8716 https://ink.library.smu.edu.sg/context/sis_research/article/9719/viewcontent/1_s2.0_S1319157824000855_pvoa_cc_nc_nd.pdf |
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