A Bayesian Decision Approach for Sample Size Determination in Phase II Trials

• Main Authors: LEUNG, Denis H. Y., WANG, You-Gan
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2001
• Subjects: Bayesian; Decision theory; Gain function; Gittins Index; Sample size; Sequential design; Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/32; https://ink.library.smu.edu.sg/context/soe_research/article/1031/viewcontent/BaynesianDecisionPhaseII_2001.pdf
• Institution: Singapore Management University

Stallard (1998, Biometrics54, 279–294) recently used Bayesian decision theory for sample-size determination in phase II trials. His design maximizes the expected financial gains in the development of a new treatment. However, it results in a very high probability (0.65) of recommending an ineffectiv...