Prognostic Impact of P53 Status in Ewing Sarcoma

• Main Authors: De Alava, E., Antonescu, C., Panizo, A., Leung, Denis H. Y., Meyers, P., Huvos, A., Pardo-Mindan, F. J., Healey, J., Ladanyi, M.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2000
• Subjects: bone tumor; translocation; point mutation; P21; Ki-67; chemotherapy response; Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/43; https://ink.library.smu.edu.sg/context/soe_research/article/1042/viewcontent/Cancer2000_89_783_pv.pdf
• Institution: Singapore Management University

Disease stage at the time of diagnosis and response to therapy are the main prognostic factors for patients with Ewing sarcoma or peripheral neuroectodermal tumor (ES/PNET). The primary genetic alteration in ES/PNET, the fusion of the EWS gene with FLI1 or ERG, is diagnostically highly specific for...