Prognostic Impact of Ink4a Deletion in Ewing Sarcoma

• Main Authors: Wei, G., Antonescu, C., De Alava, E., Leung, Denis H. Y., Huvos, A., Meyers, P., Healey, J., Ladanyi, M.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2000
• Subjects: Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/44
• Institution: Singapore Management University

BACKGROUND. The primary genetic alteration in > 95% of Ewing sarcomas (ES) is a specific fusion of EWS with FLIT or ERG. Secondary genetic alterations possibly involved in progression of ES are not well understood. A recent study found loss of the negative cell cycle regulator gene INK4A in 8 of...