Rearrangement of the Bcl-6 Gene as a Prognostic Marker in Diffuse Large-Cell Lymphoma

• Main Authors: Offit, K., Louie, D.C., Parsa, N. Z., Leung, Denis H. Y., Portlock, C., Ye, B.H., Lista, F., Filippa, D.A., Rosenbaum, A., Ladanyi, M., Jhanwar, S., Dalla-Favera, R., Changanti, R.S.K.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 1994
• Subjects: Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/92; https://ink.library.smu.edu.sg/context/soe_research/article/1091/viewcontent/nejm199407143310202_pv.pdf
• Institution: Singapore Management University

Current therapy can induce a long-term remission in half the patients with diffuse lymphomas with a large-cell component (DLLC), but more intensive treatment has the potential to improve outcome. Rearrangement of a novel candidate proto-oncogene, bcl-6, correlates with a favorable clinical outcome i...