Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors

To determine if magnetic resonance (MR) imaging findings of soft-tissue sarcoma involving bone or neurovascular structures allow prediction of local recurrence, distant metastasis, or disease-specific survival. MATERIALS AND METHODS: Preoperative MR images of 46 patients with soft-tissue sarcoma wer...

Full description

Saved in:
Bibliographic Details
Main Authors: Panicek, D., Go, S. D., Healey, J., Leung, Denis H. Y., Brennan, M. F., Lewis, J. J.
Format: text
Language:English
Published: Institutional Knowledge at Singapore Management University 1997
Subjects:
Online Access:https://ink.library.smu.edu.sg/soe_research/101
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Singapore Management University
Language: English
id sg-smu-ink.soe_research-1100
record_format dspace
spelling sg-smu-ink.soe_research-11002010-09-23T05:48:03Z Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors Panicek, D. Go, S. D. Healey, J. Leung, Denis H. Y. Brennan, M. F. Lewis, J. J. To determine if magnetic resonance (MR) imaging findings of soft-tissue sarcoma involving bone or neurovascular structures allow prediction of local recurrence, distant metastasis, or disease-specific survival. MATERIALS AND METHODS: Preoperative MR images of 46 patients with soft-tissue sarcoma were reviewed for tumor involving bone or major vessels or nerves. MR imaging findings were correlated with local recurrence, distant metastasis, and disease-specific survival after surgery and chemotherapy and/or radiation therapy. Primary tumors were predominantly in the lower extremity (n = 35 [76%]), deep (n = 44 [96%]), and high-grade (n = 35 [76%]). RESULTS: On MR images, bone invasion occurred in 12 patients (26%), major-vessel encasement in five patients (11%), and major-nerve encasement in seven patients (15%). In patients with (n = 12) and those without (n = 34) bone invasion, frequencies of disease-related death (in nine [75%] and 12 [35%] patients, respectively) were significantly different (P = .02); frequencies of local recurrence or distant metastasis were not significantly different. In patients with and those without major- vessel or major-nerve encasement, there were no significant differences between frequencies of local recurrence, distant metastasis, or disease- specific survival. CONCLUSION: In soft-tissue sarcoma, bone invasion on MR images was predictive of decreased disease-specific survival. MR imaging findings of bone or neurovascular involvement otherwise appear to be more important for tailoring surgery than for predicting local recurrence, distant metastasis, or survival. 1997-01-01T08:00:00Z text https://ink.library.smu.edu.sg/soe_research/101 Research Collection School Of Economics eng Institutional Knowledge at Singapore Management University Economics
institution Singapore Management University
building SMU Libraries
continent Asia
country Singapore
Singapore
content_provider SMU Libraries
collection InK@SMU
language English
topic Economics
spellingShingle Economics
Panicek, D.
Go, S. D.
Healey, J.
Leung, Denis H. Y.
Brennan, M. F.
Lewis, J. J.
Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors
description To determine if magnetic resonance (MR) imaging findings of soft-tissue sarcoma involving bone or neurovascular structures allow prediction of local recurrence, distant metastasis, or disease-specific survival. MATERIALS AND METHODS: Preoperative MR images of 46 patients with soft-tissue sarcoma were reviewed for tumor involving bone or major vessels or nerves. MR imaging findings were correlated with local recurrence, distant metastasis, and disease-specific survival after surgery and chemotherapy and/or radiation therapy. Primary tumors were predominantly in the lower extremity (n = 35 [76%]), deep (n = 44 [96%]), and high-grade (n = 35 [76%]). RESULTS: On MR images, bone invasion occurred in 12 patients (26%), major-vessel encasement in five patients (11%), and major-nerve encasement in seven patients (15%). In patients with (n = 12) and those without (n = 34) bone invasion, frequencies of disease-related death (in nine [75%] and 12 [35%] patients, respectively) were significantly different (P = .02); frequencies of local recurrence or distant metastasis were not significantly different. In patients with and those without major- vessel or major-nerve encasement, there were no significant differences between frequencies of local recurrence, distant metastasis, or disease- specific survival. CONCLUSION: In soft-tissue sarcoma, bone invasion on MR images was predictive of decreased disease-specific survival. MR imaging findings of bone or neurovascular involvement otherwise appear to be more important for tailoring surgery than for predicting local recurrence, distant metastasis, or survival.
format text
author Panicek, D.
Go, S. D.
Healey, J.
Leung, Denis H. Y.
Brennan, M. F.
Lewis, J. J.
author_facet Panicek, D.
Go, S. D.
Healey, J.
Leung, Denis H. Y.
Brennan, M. F.
Lewis, J. J.
author_sort Panicek, D.
title Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors
title_short Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors
title_full Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors
title_fullStr Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors
title_full_unstemmed Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors
title_sort involvement of bone or neurovascular structures by soft tissue sarcoma at mr imaging as prognostic factors
publisher Institutional Knowledge at Singapore Management University
publishDate 1997
url https://ink.library.smu.edu.sg/soe_research/101
_version_ 1770569024443252736