Statistical methods for clinical studies in the presence of surrogate end points

• Main Author: LEUNG, Denis H. Y.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2001
• Subjects: Auxiliary information; Censoring; Coarsening; Markov process; Missing values; Surrogate end points; Econometrics
• Online Access: https://ink.library.smu.edu.sg/soe_research/406; https://ink.library.smu.edu.sg/context/soe_research/article/1405/viewcontent/Leung_2001_SurrogateEndPoints.pdf
• Institution: Singapore Management University

The use of surrogate end points has become increasingly common in medical and biological research. This is primarily because, in many studies, the primary end point of interest is too expensive or too difficult to obtain. There is now a large volume of statistical methods for analysing studies with...