Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration

Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration

Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure o...

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Bibliographic Details
Main Authors: Nishiguchi, Mailyn A., Spencer, Casey A., LEUNG, Denis H. Y., Leung, Thomas H.
Format: text
Language:English
Published: Institutional Knowledge at Singapore Management University 2018
Subjects:
tissue regeneration
scar
aging
skin
epigenetics
SDF1
CXCL12
organ regeneration
Econometrics
Medical Sciences
Online Access:https://ink.library.smu.edu.sg/soe_research/2347
https://ink.library.smu.edu.sg/context/soe_research/article/3346/viewcontent/Aging_SDF1_pv.pdf
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Institution: Singapore Management University
Language: English

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https://ink.library.smu.edu.sg/soe_research/2347
https://ink.library.smu.edu.sg/context/soe_research/article/3346/viewcontent/Aging_SDF1_pv.pdf

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