Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration

• Main Authors: WEI, Jenny J., KIM, Hali S., SPENCER, Casey A., BRENNAN-CRISPI, Donna, ZHENG, Ying, JOHNSON, Nicolette M., ROSENBACH, Misha, MILLER, Christopher, LEUNG, Denis H. Y., COTSARELIS, George, LEUNG, Thomas H.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2020
• Subjects: Biostatistics; Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/2483; https://ink.library.smu.edu.sg/context/soe_research/article/3482/viewcontent/nihms_1643103.pdf
• Institution: Singapore Management University

Adult mammalian wounds, with rare exception, heal with fibrotic scars that severely disrupt tissue architecture and function. Regenerative medicine seeks methods to avoid scar formation and restore the original tissue structures. We show in three adult mouse models that pharmacologic activation of t...