Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms

The uncovering of a positive association between inflammatory cytokine levels – Interkleukin-6 (IL-6) in particular – and the experiencing of depressive and anxiety symptoms is one of the most promising and enthusiastically-discussed finding in recent years. Despite considerable ambiguity in the dir...

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Main Author: LEE, Sean Teck Hao
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Language:English
Published: Institutional Knowledge at Singapore Management University 2020
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Online Access:https://ink.library.smu.edu.sg/soss_research/3176
https://ink.library.smu.edu.sg/context/soss_research/article/4433/viewcontent/inflammation___PV.pdf
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spelling sg-smu-ink.soss_research-44332020-03-19T07:34:58Z Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms LEE, Sean Teck Hao The uncovering of a positive association between inflammatory cytokine levels – Interkleukin-6 (IL-6) in particular – and the experiencing of depressive and anxiety symptoms is one of the most promising and enthusiastically-discussed finding in recent years. Despite considerable ambiguity in the directionality and underpinnings of this association, anti-inflammatory drugs are already being tested on mental health patients who present no physical symptoms of inflammation, risking potential adverse side effects. Researchers have thus urgently called for more rigorous empirical elucidations of this association. Based on a large, longitudinal, nationally representative sample of middle-aged adults in the United States (N = 1255), IL-6 was observed to be significantly associated with one's present experiencing of depressive and anxiety symptoms. However, IL-6 was predictive of only prospective depressive (not anxiety) symptoms measured six years later, and only when baseline number of symptoms was not accounted for. Further, evidence for IL-6’s postulated role as being either a biological cause itself (augmenting HPA stress reactivity) or a biological consequence of a psychological cause (psychological stress) for depression and anxiety was not found. These findings underscore the imperativeness of more rigorous studies to be conducted in this area, and caution practitioners against the premature consideration of IL-6 levels in clinical practice. 2020-03-01T08:00:00Z text application/pdf https://ink.library.smu.edu.sg/soss_research/3176 info:doi/10.1016/j.psychres.2020.112809 https://ink.library.smu.edu.sg/context/soss_research/article/4433/viewcontent/inflammation___PV.pdf http://creativecommons.org/licenses/by-nc-nd/4.0/ Research Collection School of Social Sciences eng Institutional Knowledge at Singapore Management University Interleukin-6 Inflammation Depression Anxiety disorder Psychological stress Stress reactivity Experimental Analysis of Behavior Psychology
institution Singapore Management University
building SMU Libraries
continent Asia
country Singapore
Singapore
content_provider SMU Libraries
collection InK@SMU
language English
topic Interleukin-6
Inflammation
Depression
Anxiety disorder
Psychological stress
Stress reactivity
Experimental Analysis of Behavior
Psychology
spellingShingle Interleukin-6
Inflammation
Depression
Anxiety disorder
Psychological stress
Stress reactivity
Experimental Analysis of Behavior
Psychology
LEE, Sean Teck Hao
Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms
description The uncovering of a positive association between inflammatory cytokine levels – Interkleukin-6 (IL-6) in particular – and the experiencing of depressive and anxiety symptoms is one of the most promising and enthusiastically-discussed finding in recent years. Despite considerable ambiguity in the directionality and underpinnings of this association, anti-inflammatory drugs are already being tested on mental health patients who present no physical symptoms of inflammation, risking potential adverse side effects. Researchers have thus urgently called for more rigorous empirical elucidations of this association. Based on a large, longitudinal, nationally representative sample of middle-aged adults in the United States (N = 1255), IL-6 was observed to be significantly associated with one's present experiencing of depressive and anxiety symptoms. However, IL-6 was predictive of only prospective depressive (not anxiety) symptoms measured six years later, and only when baseline number of symptoms was not accounted for. Further, evidence for IL-6’s postulated role as being either a biological cause itself (augmenting HPA stress reactivity) or a biological consequence of a psychological cause (psychological stress) for depression and anxiety was not found. These findings underscore the imperativeness of more rigorous studies to be conducted in this area, and caution practitioners against the premature consideration of IL-6 levels in clinical practice.
format text
author LEE, Sean Teck Hao
author_facet LEE, Sean Teck Hao
author_sort LEE, Sean Teck Hao
title Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms
title_short Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms
title_full Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms
title_fullStr Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms
title_full_unstemmed Inflammation, depression, and anxiety disorder: A population-based study examining the association between Interleukin-6 and the experiencing of depressive and anxiety symptoms
title_sort inflammation, depression, and anxiety disorder: a population-based study examining the association between interleukin-6 and the experiencing of depressive and anxiety symptoms
publisher Institutional Knowledge at Singapore Management University
publishDate 2020
url https://ink.library.smu.edu.sg/soss_research/3176
https://ink.library.smu.edu.sg/context/soss_research/article/4433/viewcontent/inflammation___PV.pdf
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