Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.

Recurrent aphthous ulceration (RAU) is the most common lesion of the oral mucosa. Although many factors have been postulated as etiological factors for RAU, the role of Helicobacter pylori as a causative agent of RAU remains controversial. We therefore investigated the association of H. pylori and R...

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Main Authors: Iamaroon A., Chaimano S., Linpisarn S., Pongsiriwet S., Phornphutkul K.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0142093134&partnerID=40&md5=5967102889ef0f5596cab8ca7409de49
http://cmuir.cmu.ac.th/handle/6653943832/1089
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-10892014-08-29T09:17:44Z Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR. Iamaroon A. Chaimano S. Linpisarn S. Pongsiriwet S. Phornphutkul K. Recurrent aphthous ulceration (RAU) is the most common lesion of the oral mucosa. Although many factors have been postulated as etiological factors for RAU, the role of Helicobacter pylori as a causative agent of RAU remains controversial. We therefore investigated the association of H. pylori and RAU by a highly sensitive technique, nested polymerase chain reaction (PCR), in 22 patients with RAU with ages ranging from 12-36 years. Samples were brushed from the lesions and the dorsum of the tongue of each patient. In addition, samples from the dorsum of the tongue of 15 normal individuals with ages ranging from 13-40 years were used as controls. The results showed that only one sample from a lesion (4.5%) and one sample from the tongue (4.5%) of two different patients with RAU were positive for H. pylori. In the control group, 3 samples (20%) were positive for H. pylori. These findings suggest that H. pylori does not play a role in the pathogenesis of RAU and the dorsum of the tongue may be a reservoir of H. pylori in some individuals. 2014-08-29T09:17:44Z 2014-08-29T09:17:44Z 2003 Article 13434934 12930134 http://www.scopus.com/inward/record.url?eid=2-s2.0-0142093134&partnerID=40&md5=5967102889ef0f5596cab8ca7409de49 http://cmuir.cmu.ac.th/handle/6653943832/1089 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Recurrent aphthous ulceration (RAU) is the most common lesion of the oral mucosa. Although many factors have been postulated as etiological factors for RAU, the role of Helicobacter pylori as a causative agent of RAU remains controversial. We therefore investigated the association of H. pylori and RAU by a highly sensitive technique, nested polymerase chain reaction (PCR), in 22 patients with RAU with ages ranging from 12-36 years. Samples were brushed from the lesions and the dorsum of the tongue of each patient. In addition, samples from the dorsum of the tongue of 15 normal individuals with ages ranging from 13-40 years were used as controls. The results showed that only one sample from a lesion (4.5%) and one sample from the tongue (4.5%) of two different patients with RAU were positive for H. pylori. In the control group, 3 samples (20%) were positive for H. pylori. These findings suggest that H. pylori does not play a role in the pathogenesis of RAU and the dorsum of the tongue may be a reservoir of H. pylori in some individuals.
format Article
author Iamaroon A.
Chaimano S.
Linpisarn S.
Pongsiriwet S.
Phornphutkul K.
spellingShingle Iamaroon A.
Chaimano S.
Linpisarn S.
Pongsiriwet S.
Phornphutkul K.
Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.
author_facet Iamaroon A.
Chaimano S.
Linpisarn S.
Pongsiriwet S.
Phornphutkul K.
author_sort Iamaroon A.
title Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.
title_short Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.
title_full Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.
title_fullStr Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.
title_full_unstemmed Detection of Helicobacter pylori in recurrent aphthous ulceration by nested PCR.
title_sort detection of helicobacter pylori in recurrent aphthous ulceration by nested pcr.
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0142093134&partnerID=40&md5=5967102889ef0f5596cab8ca7409de49
http://cmuir.cmu.ac.th/handle/6653943832/1089
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