Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression

OBJECTIVES: The aims of the study were to assess sociodemographic and clinicopathologic characteristics of patients with oral non-Hodgkin lymphomas (NHLs) and the expression of Epstein-Barr virus (EBV) and p53. MATERIALS AND METHODS: The clinical and pathologic features of 11 patients with oral NHLs...

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Main Authors: Iamaroon A., Pongsiriwet S., Mahanupab P., Kitikamthon R., Pintong J.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0037283907&partnerID=40&md5=0c25406a419c063c61d15530b47e0926
http://www.ncbi.nlm.nih.gov/pubmed/12617252
http://cmuir.cmu.ac.th/handle/6653943832/1120
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-11202014-08-29T09:17:46Z Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression Iamaroon A. Pongsiriwet S. Mahanupab P. Kitikamthon R. Pintong J. OBJECTIVES: The aims of the study were to assess sociodemographic and clinicopathologic characteristics of patients with oral non-Hodgkin lymphomas (NHLs) and the expression of Epstein-Barr virus (EBV) and p53. MATERIALS AND METHODS: The clinical and pathologic features of 11 patients with oral NHLs were studied. The expression of EBV mRNA and p53 protein were studied by means of in situ hybridization and immunohistochemical methods in 11 formalin-fixed, paraffin-embedded specimens from these patients. RESULTS: The patients' age ranged from 13 to 70 years with the mean of 42 years. Human immuno-deficiency virus (HIV) status was documented in five of the 11 patients and three were known to be HIV-positive. The most common locations were gingiva and alveolar mucosa. Pain and tenderness were major symptoms of the patients. The most common histologic subtype was diffuse large-cell, intermediate-grade NHL. Eight of 11 cases (72.7%) showed positive expression of p53 protein. Four of 10 cases (40%) expressed EBV-encoded RNA (EBER) transcripts. All known HIV-positive cases were EBV-positive. CONCLUSIONS: The findings suggest that appropriately expressed p53 protein may play a role in tumorigenesis of oral NHLs. In addition, EBV may be involved with the pathogenesis of oral NHLs particularly in patients with HIV infection. 2014-08-29T09:17:46Z 2014-08-29T09:17:46Z 2003 Article 1354523X 10.1034/j.1601-0825.2003.01808.x 12617252 ORDIF http://www.scopus.com/inward/record.url?eid=2-s2.0-0037283907&partnerID=40&md5=0c25406a419c063c61d15530b47e0926 http://www.ncbi.nlm.nih.gov/pubmed/12617252 http://cmuir.cmu.ac.th/handle/6653943832/1120 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description OBJECTIVES: The aims of the study were to assess sociodemographic and clinicopathologic characteristics of patients with oral non-Hodgkin lymphomas (NHLs) and the expression of Epstein-Barr virus (EBV) and p53. MATERIALS AND METHODS: The clinical and pathologic features of 11 patients with oral NHLs were studied. The expression of EBV mRNA and p53 protein were studied by means of in situ hybridization and immunohistochemical methods in 11 formalin-fixed, paraffin-embedded specimens from these patients. RESULTS: The patients' age ranged from 13 to 70 years with the mean of 42 years. Human immuno-deficiency virus (HIV) status was documented in five of the 11 patients and three were known to be HIV-positive. The most common locations were gingiva and alveolar mucosa. Pain and tenderness were major symptoms of the patients. The most common histologic subtype was diffuse large-cell, intermediate-grade NHL. Eight of 11 cases (72.7%) showed positive expression of p53 protein. Four of 10 cases (40%) expressed EBV-encoded RNA (EBER) transcripts. All known HIV-positive cases were EBV-positive. CONCLUSIONS: The findings suggest that appropriately expressed p53 protein may play a role in tumorigenesis of oral NHLs. In addition, EBV may be involved with the pathogenesis of oral NHLs particularly in patients with HIV infection.
format Article
author Iamaroon A.
Pongsiriwet S.
Mahanupab P.
Kitikamthon R.
Pintong J.
spellingShingle Iamaroon A.
Pongsiriwet S.
Mahanupab P.
Kitikamthon R.
Pintong J.
Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression
author_facet Iamaroon A.
Pongsiriwet S.
Mahanupab P.
Kitikamthon R.
Pintong J.
author_sort Iamaroon A.
title Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression
title_short Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression
title_full Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression
title_fullStr Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression
title_full_unstemmed Oral non-Hodgkin lymphomas: Studies of EBV and p53 expression
title_sort oral non-hodgkin lymphomas: studies of ebv and p53 expression
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0037283907&partnerID=40&md5=0c25406a419c063c61d15530b47e0926
http://www.ncbi.nlm.nih.gov/pubmed/12617252
http://cmuir.cmu.ac.th/handle/6653943832/1120
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