Role of p38 inhibition in cardiac ischemia/reperfusion injury

The p38 mitogen-activated protein kinases (p38s) are Ser/Thr kinases that are activated as a result of cellular stresses and various pathological conditions, including myocardial ischemia/reperfusion. p38 activation has been shown to accentuate myocardial injury and impair cardiac function. Inhibiti...

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Main Authors: Kumphune S., Chattipakorn S., Chattipakorn N.
Format: Review
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84864278617&partnerID=40&md5=97428fd3d3bff89d58152339b18185a3
http://www.ncbi.nlm.nih.gov/pubmed/22205273
http://cmuir.cmu.ac.th/handle/6653943832/1124
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-11242014-08-29T09:17:46Z Role of p38 inhibition in cardiac ischemia/reperfusion injury Kumphune S. Chattipakorn S. Chattipakorn N. The p38 mitogen-activated protein kinases (p38s) are Ser/Thr kinases that are activated as a result of cellular stresses and various pathological conditions, including myocardial ischemia/reperfusion. p38 activation has been shown to accentuate myocardial injury and impair cardiac function. Inhibition of p38 activation and its activity has been proposed to be cardioprotective by slowing the rate of myocardial damage and improving cardiac function. The growing body of evidence on the use of p38 inhibitors as therapeutic means for responding to heart problems is controversial, since both beneficial as well as a lack of protective effects on the heart have been reported. In this review, the outcomes from studies investigating the effect of p38 inhibitors on the heart in a wide range of study models, including in vitro, ex vivo, and in vivo models, are discussed. The correlations of experimental models with practical clinical usefulness, as well as the need for future studies regarding the use of p38 inhibitors, are also addressed. © Springer-Verlag 2011. 2014-08-29T09:17:46Z 2014-08-29T09:17:46Z 2012 Review 316970 10.1007/s00228-011-1193-2 22205273 EJCPA http://www.scopus.com/inward/record.url?eid=2-s2.0-84864278617&partnerID=40&md5=97428fd3d3bff89d58152339b18185a3 http://www.ncbi.nlm.nih.gov/pubmed/22205273 http://cmuir.cmu.ac.th/handle/6653943832/1124 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The p38 mitogen-activated protein kinases (p38s) are Ser/Thr kinases that are activated as a result of cellular stresses and various pathological conditions, including myocardial ischemia/reperfusion. p38 activation has been shown to accentuate myocardial injury and impair cardiac function. Inhibition of p38 activation and its activity has been proposed to be cardioprotective by slowing the rate of myocardial damage and improving cardiac function. The growing body of evidence on the use of p38 inhibitors as therapeutic means for responding to heart problems is controversial, since both beneficial as well as a lack of protective effects on the heart have been reported. In this review, the outcomes from studies investigating the effect of p38 inhibitors on the heart in a wide range of study models, including in vitro, ex vivo, and in vivo models, are discussed. The correlations of experimental models with practical clinical usefulness, as well as the need for future studies regarding the use of p38 inhibitors, are also addressed. © Springer-Verlag 2011.
format Review
author Kumphune S.
Chattipakorn S.
Chattipakorn N.
spellingShingle Kumphune S.
Chattipakorn S.
Chattipakorn N.
Role of p38 inhibition in cardiac ischemia/reperfusion injury
author_facet Kumphune S.
Chattipakorn S.
Chattipakorn N.
author_sort Kumphune S.
title Role of p38 inhibition in cardiac ischemia/reperfusion injury
title_short Role of p38 inhibition in cardiac ischemia/reperfusion injury
title_full Role of p38 inhibition in cardiac ischemia/reperfusion injury
title_fullStr Role of p38 inhibition in cardiac ischemia/reperfusion injury
title_full_unstemmed Role of p38 inhibition in cardiac ischemia/reperfusion injury
title_sort role of p38 inhibition in cardiac ischemia/reperfusion injury
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84864278617&partnerID=40&md5=97428fd3d3bff89d58152339b18185a3
http://www.ncbi.nlm.nih.gov/pubmed/22205273
http://cmuir.cmu.ac.th/handle/6653943832/1124
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