Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

• Main Authors: Pintana H., Apaijai N., Pratchayasakul W., Chattipakorn N., Chattipakorn S.C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84866365752&partnerID=40&md5=e91055456ef82d5f42bdf5f0f7301227; http://www.ncbi.nlm.nih.gov/pubmed/22925597; http://cmuir.cmu.ac.th/handle/6653943832/1150
• Institution: Chiang Mai University

Aim: Metformin is a first line drug for the treatment of type 2 diabetes mellitus (T2DM). Our previous study reported that high-fat diet (HFD) consumption caused not only peripheral and neuronal insulin resistance, but also induced brain mitochondrial dysfunction as well as learning impairment. Howe...