Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

• المؤلفون الرئيسيون: Sripetchwandee J., Sanit J., Chattipakorn N., Chattipakorn S.C.
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الوصول للمادة أونلاين: http://www.scopus.com/inward/record.url?eid=2-s2.0-84873713188&partnerID=40&md5=f26d8a0df6d0b9aaaebcf688371e3760; http://www.ncbi.nlm.nih.gov/pubmed/23333832; http://cmuir.cmu.ac.th/handle/6653943832/1162
• المؤسسة: Chiang Mai University

Aims Although iron overload induces oxidative stress and brain mitochondrial dysfunction, and is associated with neurodegenerative diseases, brain mitochondrial iron uptake has not been investigated. We determined the role of mitochondrial calcium uniporter (MCU) in brain mitochondria as a major rou...