Dipeptidyl peptidase-4 inhibitor reduces infarct size and preserves cardiac function via mitochondrial protection in ischaemia-reperfusion rat heart

• Main Authors: Chinda K., Sanit J., Chattipakorn S., Chattipakorn N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84894488315&partnerID=40&md5=27a42fe85ff4ba125c96739a0978391d; http://cmuir.cmu.ac.th/handle/6653943832/1681
• Institution: Chiang Mai University

Aim: We hypothesized that dipeptidyl peptidase (DPP)-4 inhibitor (vildagliptin) reduces fatal arrhythmias, cardiac dysfunction and infarct size caused by ischaemiareperfusion (I/R) injury via its attenuation of cardiac mitochondrial dysfunction. Methods: In total, 26 rats were randomized to receive...