Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix

Background: To examine the incidence of positive vaginal surgical margins and determine the predicting factors following radical hysterectomy for stage IB1 carcinoma of the cervix. Materials and Methods: The clinical and histological data of 656 FIGO stage IB1 cervical cancer patients who had radica...

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Main Authors: Sethasathien S., Charoenkwan K., Settakorn J., Srisomboon J.
Format: Article
Language:English
Published: Asian Pacific Organization for Cancer Prevention 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/24716959
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spelling th-cmuir.6653943832-17212014-08-30T01:59:59Z Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix Sethasathien S. Charoenkwan K. Settakorn J. Srisomboon J. Background: To examine the incidence of positive vaginal surgical margins and determine the predicting factors following radical hysterectomy for stage IB1 carcinoma of the cervix. Materials and Methods: The clinical and histological data of 656 FIGO stage IB1 cervical cancer patients who had radical hysterectomy with bilateral pelvic lymphadenectomy (RHPL) from January 2003 to December 2012 were retrospectively reviewed and were analyzed for their association with a positive vaginal surgical margin. A p-value of < 0.05 was considered significant. Results: Thirty-five patients (5.3%) had positive vaginal surgical margins following RHPL; 24 (3.7%) for intraepithelial lesions and 11 (1.7%) for carcinoma. On multivariate analysis, microscopic vaginal involvement by high-grade squamous intraepithelial lesion and/or carcinoma (adjusted odd ratio (OR) 186.8; 95% confidence interval (CI) 48.5-718.5) and squamous histology (OR 8.7; 95% CI 1.7-44.0), were significantly associated with positive vaginal surgical margin. Conclusions: Microscopic vaginal involvement by HSIL and/ or carcinoma are strong predictors for positive vaginal surgical margins for stage IB1 cervical cancer patients undergoing radical hysterectomy. Preoperative 'mapping' colposcopy or other strategies should be considered to ensure optimal vaginal resection. 2014-08-30T01:59:59Z 2014-08-30T01:59:59Z 2014 Article 15137368 10.7314/APJCP.2014.15.5.2211 http://www.ncbi.nlm.nih.gov/pubmed/24716959 http://www.scopus.com/inward/record.url?eid=2-s2.0-84899127875&partnerID=40&md5=500c9682971da92977850294e27825d0 http://cmuir.cmu.ac.th/handle/6653943832/1721 English Asian Pacific Organization for Cancer Prevention
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background: To examine the incidence of positive vaginal surgical margins and determine the predicting factors following radical hysterectomy for stage IB1 carcinoma of the cervix. Materials and Methods: The clinical and histological data of 656 FIGO stage IB1 cervical cancer patients who had radical hysterectomy with bilateral pelvic lymphadenectomy (RHPL) from January 2003 to December 2012 were retrospectively reviewed and were analyzed for their association with a positive vaginal surgical margin. A p-value of < 0.05 was considered significant. Results: Thirty-five patients (5.3%) had positive vaginal surgical margins following RHPL; 24 (3.7%) for intraepithelial lesions and 11 (1.7%) for carcinoma. On multivariate analysis, microscopic vaginal involvement by high-grade squamous intraepithelial lesion and/or carcinoma (adjusted odd ratio (OR) 186.8; 95% confidence interval (CI) 48.5-718.5) and squamous histology (OR 8.7; 95% CI 1.7-44.0), were significantly associated with positive vaginal surgical margin. Conclusions: Microscopic vaginal involvement by HSIL and/ or carcinoma are strong predictors for positive vaginal surgical margins for stage IB1 cervical cancer patients undergoing radical hysterectomy. Preoperative 'mapping' colposcopy or other strategies should be considered to ensure optimal vaginal resection.
format Article
author Sethasathien S.
Charoenkwan K.
Settakorn J.
Srisomboon J.
spellingShingle Sethasathien S.
Charoenkwan K.
Settakorn J.
Srisomboon J.
Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
author_facet Sethasathien S.
Charoenkwan K.
Settakorn J.
Srisomboon J.
author_sort Sethasathien S.
title Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
title_short Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
title_full Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
title_fullStr Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
title_full_unstemmed Predicting Factors for Positive Vaginal Surgical Margin Following Radical Hysterectomy for Stage IB1 Carcinoma of the Cervix
title_sort predicting factors for positive vaginal surgical margin following radical hysterectomy for stage ib1 carcinoma of the cervix
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/24716959
http://www.scopus.com/inward/record.url?eid=2-s2.0-84899127875&partnerID=40&md5=500c9682971da92977850294e27825d0
http://cmuir.cmu.ac.th/handle/6653943832/1721
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