Estrogen restores brain insulin sensitivity in ovariectomized non-obese rats, but not in ovariectomized obese rats

• Main Authors: Pratchayasakul W., Chattipakorn N., Chattipakorn S.C.
• Format: Article
• Language: English
• Published: W.B. Saunders 2014
• Online Access: http://www.ncbi.nlm.nih.gov/pubmed/24742706; http://www.scopus.com/inward/record.url?eid=2-s2.0-84901230932&partnerID=40&md5=ffcfb71f8e057748ce5cf1dfac92d490; http://cmuir.cmu.ac.th/handle/6653943832/1726
• Institution: Chiang Mai University

Objective We previously demonstrated that obesity caused the reduction of peripheral and brain insulin sensitivity and that estrogen therapy improved these defects. However, the beneficial effect of estrogen on brain insulin sensitivity and oxidative stress in either ovariectomy alone or ovariectomy...