Impact of gastrointestinal endoscopy on HIV-infected children

Objective: To evaluate the role of gastrointestinal (GI) endoscopy in human immunodeficiency virus (HIV)-infected children with GI problems. Methods: From 1998 to 2002, we retrospectively reviewed all cases of HIV-infected children presenting with GI problems in which an upper or lower GI endoscopy...

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Main Authors: Ukarapol N., Lertprasertsuk N., Fuchs G.J., Wongsawasdi L., Sirisanthana V.
Format: Review
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-1542318209&partnerID=40&md5=fde6f3d4c27881fd02cfb37e5eeb9cb1
http://cmuir.cmu.ac.th/handle/6653943832/1754
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-17542014-08-30T02:00:04Z Impact of gastrointestinal endoscopy on HIV-infected children Ukarapol N. Lertprasertsuk N. Fuchs G.J. Wongsawasdi L. Sirisanthana V. Objective: To evaluate the role of gastrointestinal (GI) endoscopy in human immunodeficiency virus (HIV)-infected children with GI problems. Methods: From 1998 to 2002, we retrospectively reviewed all cases of HIV-infected children presenting with GI problems in which an upper or lower GI endoscopy was indicated. The initial diagnostic endoscopic examination and any repeat endoscopic session leading to a new diagnosis were used in the data analysis. Tissue biopsies were obtained from all abnormal lesions and representative sites of normal-appearancing GI mucosa. Results: Fourteen patients (median age: 22.5 months) underwent 23 sessions of GI endoscopy, including 10 esophagogastroduodenoscopy, nine colonoscopy and four flexible sigmoidoscopy. Chronic diarrhea was the most common indication, followed by lower GI bleeding, abdominal/retrosternal pain, dysphagia/odynophagia, and upper GI bleeding. Gross endoscopic abnormalities were observed in 78.3%; whereas histological inflammation and opportunistic pathogens were identified in 87% and 43.5%, respectively. Cytomegalovirus was the most common identified pathogen. Abnormal gross findings were significantly associated with histological inflammation and identification of pathogens (P = 0.006 and 0.046, respectively). Specific changes in medical management were made in 50% of cases as a result of endoscopic investigation. Conclusion: If non-invasive investigations for HIV-infected children with GI symptoms fail to establish a diagnosis, gastrointestinal endoscopy should be performed and often yields a positive result leading to changes in medical management. 2014-08-30T02:00:03Z 2014-08-30T02:00:03Z 2004 Review 09155635 10.1111/j.1443-1661.2004.00310.x DIENE http://www.scopus.com/inward/record.url?eid=2-s2.0-1542318209&partnerID=40&md5=fde6f3d4c27881fd02cfb37e5eeb9cb1 http://cmuir.cmu.ac.th/handle/6653943832/1754 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To evaluate the role of gastrointestinal (GI) endoscopy in human immunodeficiency virus (HIV)-infected children with GI problems. Methods: From 1998 to 2002, we retrospectively reviewed all cases of HIV-infected children presenting with GI problems in which an upper or lower GI endoscopy was indicated. The initial diagnostic endoscopic examination and any repeat endoscopic session leading to a new diagnosis were used in the data analysis. Tissue biopsies were obtained from all abnormal lesions and representative sites of normal-appearancing GI mucosa. Results: Fourteen patients (median age: 22.5 months) underwent 23 sessions of GI endoscopy, including 10 esophagogastroduodenoscopy, nine colonoscopy and four flexible sigmoidoscopy. Chronic diarrhea was the most common indication, followed by lower GI bleeding, abdominal/retrosternal pain, dysphagia/odynophagia, and upper GI bleeding. Gross endoscopic abnormalities were observed in 78.3%; whereas histological inflammation and opportunistic pathogens were identified in 87% and 43.5%, respectively. Cytomegalovirus was the most common identified pathogen. Abnormal gross findings were significantly associated with histological inflammation and identification of pathogens (P = 0.006 and 0.046, respectively). Specific changes in medical management were made in 50% of cases as a result of endoscopic investigation. Conclusion: If non-invasive investigations for HIV-infected children with GI symptoms fail to establish a diagnosis, gastrointestinal endoscopy should be performed and often yields a positive result leading to changes in medical management.
format Review
author Ukarapol N.
Lertprasertsuk N.
Fuchs G.J.
Wongsawasdi L.
Sirisanthana V.
spellingShingle Ukarapol N.
Lertprasertsuk N.
Fuchs G.J.
Wongsawasdi L.
Sirisanthana V.
Impact of gastrointestinal endoscopy on HIV-infected children
author_facet Ukarapol N.
Lertprasertsuk N.
Fuchs G.J.
Wongsawasdi L.
Sirisanthana V.
author_sort Ukarapol N.
title Impact of gastrointestinal endoscopy on HIV-infected children
title_short Impact of gastrointestinal endoscopy on HIV-infected children
title_full Impact of gastrointestinal endoscopy on HIV-infected children
title_fullStr Impact of gastrointestinal endoscopy on HIV-infected children
title_full_unstemmed Impact of gastrointestinal endoscopy on HIV-infected children
title_sort impact of gastrointestinal endoscopy on hiv-infected children
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-1542318209&partnerID=40&md5=fde6f3d4c27881fd02cfb37e5eeb9cb1
http://cmuir.cmu.ac.th/handle/6653943832/1754
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