Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454)

Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454)

A novel gene, dfrG, encoding a trimethoprim (TMP)-resistant dihydrofolate reductase (DHFR, designated S3DHFR) was cloned from a clinical isolate of methicillin-resistant Staphylococcus aureus. Escherichia coli expressing dfrG was highly resistant to TMP. Recombinant S3DHFR exhibited DHFR activity th...

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Bibliographic Details
Main Authors: Sekiguchi J.-I., Tharavichitkul P., Miyoshi-Akiyama T., Chupia V., Fujino T., Araake M., Irie A., Morita K., Kuratsuji T., Kirikae T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-24144502081&partnerID=40&md5=21331009581d9556813368410339cbcb
http://cmuir.cmu.ac.th/handle/6653943832/1858
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Institution: Chiang Mai University
Language: English

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http://www.scopus.com/inward/record.url?eid=2-s2.0-24144502081&partnerID=40&md5=21331009581d9556813368410339cbcb
http://cmuir.cmu.ac.th/handle/6653943832/1858

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