Molecular and clinical features of Hb H disease in northern Thailand

• Main Authors: Charoenkwan P., Taweephon R., Sae-Tung R., Thanarattanakorn P., Sanguansermsri T.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-18844409532&partnerID=40&md5=71784ca68f91eb65199d54c8e968d5cd; http://www.ncbi.nlm.nih.gov/pubmed/15921165; http://cmuir.cmu.ac.th/handle/6653943832/1914
• Institution: Chiang Mai University

Clinical assessment, hematological studies and molecular analyses were performed in 102 pediatric patients with Hb H disease in northern Thailand. A total of six mutations of the α-globin gene, which produced five genotypes, were detected. All patients had an α0-thalassemia (thal) deletion on one ch...