Prenatal diagnosis of β-thalassemia major by high-performance liquid chromatography analysis of hemoglobins in fetal blood samples

• Main Authors: Sanguansermsri T., Thanarattanakorn P., Steger H.F., Tongsong T., Chanprapaph P., Wanpirak C., Siriwatanapa P., Sirichotiyakul S., Flatz G.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035088922&partnerID=40&md5=3d662b5ad529c2f076ec3f3e17b56bc8; http://cmuir.cmu.ac.th/handle/6653943832/1923
• Institution: Chiang Mai University

In Thailand and adjacent countries, most of the β-thalassemia genes are β0-thalassemia mutations that prevent the production of Hb A. We propose the quantitation of the Hb A fraction in fetal blood in the mid-trimester of pregnancy by automated high performance liquid chromatography as a reasonable...