Yolk sac tumor of the vulva: A case report with long-term disease-free survival

Background. Yolk sac tumor (YST) of the vulva is extremely rare. Seven cases of vulvar YST have been reported to the literature. Due to the rarity of tumors, the appropriate choice of treatment may remain unclear. Case. A 30-year-old woman presented with a 3.5-cm right labial mass. Excisional biopsy...

Full description

Saved in:
Bibliographic Details
Main Authors: Khunamornpong S., Siriaunkgul S., Suprasert P., Chitapanarux I.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-15544378665&partnerID=40&md5=ad79080673f81fe07dee8e0fe13760e9
http://www.ncbi.nlm.nih.gov/pubmed/15790466
http://cmuir.cmu.ac.th/handle/6653943832/1929
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
id th-cmuir.6653943832-1929
record_format dspace
spelling th-cmuir.6653943832-19292014-08-30T02:00:16Z Yolk sac tumor of the vulva: A case report with long-term disease-free survival Khunamornpong S. Siriaunkgul S. Suprasert P. Chitapanarux I. Background. Yolk sac tumor (YST) of the vulva is extremely rare. Seven cases of vulvar YST have been reported to the literature. Due to the rarity of tumors, the appropriate choice of treatment may remain unclear. Case. A 30-year-old woman presented with a 3.5-cm right labial mass. Excisional biopsy showed YST with predominant solid pattern. Three weeks after excision, right inguinal lymph node biopsy revealed metastatic tumor. The serum alpha-fetoprotein (AFP) was not elevated. Cisplatin-based chemotherapy was administered, followed by pelvic and groin irradiation. The patient was free of disease 90 months after the diagnosis. Conclusion. Local excision of tumor with adjuvant cisplatin-based chemotherapy can be justified for vulvar YST. Inguinal lymphadenectomy is recommended because metastasis may occur early. Adjuvant radiation therapy may help to control the disease. Tumor size of 5 cm or less may be a favorable prognostic factor. Serum AFP level may not be a sensitive marker for follow-up of vulvar YST. © 2005 Elsevier Inc. All rights reserved. 2014-08-30T02:00:16Z 2014-08-30T02:00:16Z 2005 Article 00908258 10.1016/j.ygyno.2004.12.054 15790466 GYNOA http://www.scopus.com/inward/record.url?eid=2-s2.0-15544378665&partnerID=40&md5=ad79080673f81fe07dee8e0fe13760e9 http://www.ncbi.nlm.nih.gov/pubmed/15790466 http://cmuir.cmu.ac.th/handle/6653943832/1929 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background. Yolk sac tumor (YST) of the vulva is extremely rare. Seven cases of vulvar YST have been reported to the literature. Due to the rarity of tumors, the appropriate choice of treatment may remain unclear. Case. A 30-year-old woman presented with a 3.5-cm right labial mass. Excisional biopsy showed YST with predominant solid pattern. Three weeks after excision, right inguinal lymph node biopsy revealed metastatic tumor. The serum alpha-fetoprotein (AFP) was not elevated. Cisplatin-based chemotherapy was administered, followed by pelvic and groin irradiation. The patient was free of disease 90 months after the diagnosis. Conclusion. Local excision of tumor with adjuvant cisplatin-based chemotherapy can be justified for vulvar YST. Inguinal lymphadenectomy is recommended because metastasis may occur early. Adjuvant radiation therapy may help to control the disease. Tumor size of 5 cm or less may be a favorable prognostic factor. Serum AFP level may not be a sensitive marker for follow-up of vulvar YST. © 2005 Elsevier Inc. All rights reserved.
format Article
author Khunamornpong S.
Siriaunkgul S.
Suprasert P.
Chitapanarux I.
spellingShingle Khunamornpong S.
Siriaunkgul S.
Suprasert P.
Chitapanarux I.
Yolk sac tumor of the vulva: A case report with long-term disease-free survival
author_facet Khunamornpong S.
Siriaunkgul S.
Suprasert P.
Chitapanarux I.
author_sort Khunamornpong S.
title Yolk sac tumor of the vulva: A case report with long-term disease-free survival
title_short Yolk sac tumor of the vulva: A case report with long-term disease-free survival
title_full Yolk sac tumor of the vulva: A case report with long-term disease-free survival
title_fullStr Yolk sac tumor of the vulva: A case report with long-term disease-free survival
title_full_unstemmed Yolk sac tumor of the vulva: A case report with long-term disease-free survival
title_sort yolk sac tumor of the vulva: a case report with long-term disease-free survival
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-15544378665&partnerID=40&md5=ad79080673f81fe07dee8e0fe13760e9
http://www.ncbi.nlm.nih.gov/pubmed/15790466
http://cmuir.cmu.ac.th/handle/6653943832/1929
_version_ 1681419762252382208