Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand

Hepatocellular carcinoma is one of the leading causes of cancer death worldwide. The etiology of liver cancer is multifactorial, and infection with hepatitis B virus (HBV), whose pathogenesis is exacerbated by the acquisition of mutations that accelerate carcinogenesis, or hepatitis C virus (HCV) an...

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Main Authors: Kuang S.-Y., Lekawanvijit S., Maneekarn N., Thongsawat S., Brodovicz K., Nelson K., Groopman J.D.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-13944251714&partnerID=40&md5=9dba9d81f32deeee927e5e33051ee1b6
http://cmuir.cmu.ac.th/handle/6653943832/1961
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-19612014-08-30T02:00:19Z Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand Kuang S.-Y. Lekawanvijit S. Maneekarn N. Thongsawat S. Brodovicz K. Nelson K. Groopman J.D. Hepatocellular carcinoma is one of the leading causes of cancer death worldwide. The etiology of liver cancer is multifactorial, and infection with hepatitis B virus (HBV), whose pathogenesis is exacerbated by the acquisition of mutations that accelerate carcinogenesis, or hepatitis C virus (HCV) and dietary exposure to aflatoxin B1 all contribute to elevating one's risk for this disease. In this study, we sought to determine the contributions of these agents by measuring the occurrence of an HBV 1762T/1764 A double mutation, an aflatoxin-specific 249G→T mutation of the p53 gene, and HCV in plasma of 34 HCC cases and 68 age- and gender-matched controls, and in 25 liver tumors from northern Thailand. In total, 14 cases, 5 controls, and 19 tumors had detectable levels of HBV DNA. All 14 cases, 2 controls (2.9%), and 17 tumors (89.5%) were positive for the HBV double mutation. Nine cases (26.5%), 10 controls (14.7%), and 6 tumors (24%) were positive for the p53 mutation. Five cases (14.7%), no controls, and 4 rumors (16%) had both mutations. The median age of HCC diagnosis in these 5 cases was 34 years versus 51 years for other cases. Five cases (14.7%) and 1 control (1.5%) were HCV enzyme immunoassay positive. Thus, specific HBV, HCV, and aflatoxin biomarkers reveal the complexity of risks contributing to HCC in northern Thailand and suggest further application of these biomarkers as intermediate end points in prevention, intervention trials, and etiologic investigations. 2014-08-30T02:00:19Z 2014-08-30T02:00:19Z 2005 Article 10559965 10.1158/1055-9965.EPI-04-0380 15734961 CEBPE http://www.scopus.com/inward/record.url?eid=2-s2.0-13944251714&partnerID=40&md5=9dba9d81f32deeee927e5e33051ee1b6 http://cmuir.cmu.ac.th/handle/6653943832/1961 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Hepatocellular carcinoma is one of the leading causes of cancer death worldwide. The etiology of liver cancer is multifactorial, and infection with hepatitis B virus (HBV), whose pathogenesis is exacerbated by the acquisition of mutations that accelerate carcinogenesis, or hepatitis C virus (HCV) and dietary exposure to aflatoxin B1 all contribute to elevating one's risk for this disease. In this study, we sought to determine the contributions of these agents by measuring the occurrence of an HBV 1762T/1764 A double mutation, an aflatoxin-specific 249G→T mutation of the p53 gene, and HCV in plasma of 34 HCC cases and 68 age- and gender-matched controls, and in 25 liver tumors from northern Thailand. In total, 14 cases, 5 controls, and 19 tumors had detectable levels of HBV DNA. All 14 cases, 2 controls (2.9%), and 17 tumors (89.5%) were positive for the HBV double mutation. Nine cases (26.5%), 10 controls (14.7%), and 6 tumors (24%) were positive for the p53 mutation. Five cases (14.7%), no controls, and 4 rumors (16%) had both mutations. The median age of HCC diagnosis in these 5 cases was 34 years versus 51 years for other cases. Five cases (14.7%) and 1 control (1.5%) were HCV enzyme immunoassay positive. Thus, specific HBV, HCV, and aflatoxin biomarkers reveal the complexity of risks contributing to HCC in northern Thailand and suggest further application of these biomarkers as intermediate end points in prevention, intervention trials, and etiologic investigations.
format Article
author Kuang S.-Y.
Lekawanvijit S.
Maneekarn N.
Thongsawat S.
Brodovicz K.
Nelson K.
Groopman J.D.
spellingShingle Kuang S.-Y.
Lekawanvijit S.
Maneekarn N.
Thongsawat S.
Brodovicz K.
Nelson K.
Groopman J.D.
Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
author_facet Kuang S.-Y.
Lekawanvijit S.
Maneekarn N.
Thongsawat S.
Brodovicz K.
Nelson K.
Groopman J.D.
author_sort Kuang S.-Y.
title Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
title_short Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
title_full Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
title_fullStr Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
title_full_unstemmed Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
title_sort hepatitis b 1762t/1764a mutations, hepatitis c infection, and codon 249 p53 mutations in hepatocellular carcinomas from thailand
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-13944251714&partnerID=40&md5=9dba9d81f32deeee927e5e33051ee1b6
http://cmuir.cmu.ac.th/handle/6653943832/1961
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