Intravitreal foscarnet for cytomegalovirus retinitis in patients with AIDS
To determine the visual outcome, progression, and complications of patients with acquired immunodeficiency syndrome-related cytomegalovirus (CMV) retinitis treated with intravitreal foscarnet (2.4 mg in 0.1 ml per injection), a retrospective study was carried out in 193 patients. Induction therapy c...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-20444472320&partnerID=40&md5=b16aa4282b84ec18b8998b4cdf0e0e61 http://www.ncbi.nlm.nih.gov/pubmed/15960227 http://cmuir.cmu.ac.th/handle/6653943832/1970 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | To determine the visual outcome, progression, and complications of patients with acquired immunodeficiency syndrome-related cytomegalovirus (CMV) retinitis treated with intravitreal foscarnet (2.4 mg in 0.1 ml per injection), a retrospective study was carried out in 193 patients. Induction therapy consisted of two injections a week until the lesions were inactive. Maintenance therapy consisted of one injection a week until relapse, then re-induction was instituted. In 301 treated eyes, visual acuity remained stable in 184 (61%), improved in 16 (5%), and decreased in 101 (34%). Of these, 15 retinal detachments, 13 intravitreal hemorrhages, 3 endophthalmitis, and 2 cataract occurred. Median time of first progression was 15 weeks. Involvement of the fellow eye occurred in 35% of the patients during treatment of the first eye. Intravitreal foscarnet appeared to be a useful alternative treatment for patients intolerant or unaffordable to intravenous anti-CMV drugs, but the complications of this treatment should also be considered. |
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