Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer

A prospectively designed phase II study of non-small cell lung cancer stage IIIb and IV treated by gemcitabine and cisplatin was studied. The dosage of gemcitabine was lg/m2 weekly on day 1, 8 and 15. Cisplatin 100 mg/m2 was given on day 15 of each 28 day cycle. Twenty-eight patients were treated an...

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Main Authors: Thongprasert S., Chewaskulyong B., Pothirat C.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0034849569&partnerID=40&md5=b3a2dbd695d69b2add961e0a458f9817
http://www.ncbi.nlm.nih.gov/pubmed/11460942
http://cmuir.cmu.ac.th/handle/6653943832/1983
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-19832014-08-30T02:00:21Z Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer Thongprasert S. Chewaskulyong B. Pothirat C. A prospectively designed phase II study of non-small cell lung cancer stage IIIb and IV treated by gemcitabine and cisplatin was studied. The dosage of gemcitabine was lg/m2 weekly on day 1, 8 and 15. Cisplatin 100 mg/m2 was given on day 15 of each 28 day cycle. Twenty-eight patients were treated and all cases were evaluated for response. Survival and toxicity were determined in all enrolled patients. Thirteen (46.4%) achieved partial response (PR). By using Kaplan Meier's method the mean survival time was 19.8 months. One year survival was 66.6 per cent. Non hematologic toxicity consisted of mild nausea, vomiting, alopecia and hyperpigmentation of the skin. Rising creatinine of grade I was seen in 1.6 per cent. Anemia and leukopenia were common hematologic side effects with 27.5 per cent and 14.2 per cent of patients experiencing grade III and IV toxicity respectively. Both side effects were usually short lived and responsible for the delay of gemcitabine administration on day 8 and 15 in 18.3 per cent and 23.3 per cent on day 15 alone of chemotherapeutic courses respectively. We conclude that the combination of gemcitabine and cisplatin at this dosage achieved good response with moderate side effects. 2014-08-30T02:00:21Z 2014-08-30T02:00:21Z 2001 Article 01252208 11460942 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-0034849569&partnerID=40&md5=b3a2dbd695d69b2add961e0a458f9817 http://www.ncbi.nlm.nih.gov/pubmed/11460942 http://cmuir.cmu.ac.th/handle/6653943832/1983 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description A prospectively designed phase II study of non-small cell lung cancer stage IIIb and IV treated by gemcitabine and cisplatin was studied. The dosage of gemcitabine was lg/m2 weekly on day 1, 8 and 15. Cisplatin 100 mg/m2 was given on day 15 of each 28 day cycle. Twenty-eight patients were treated and all cases were evaluated for response. Survival and toxicity were determined in all enrolled patients. Thirteen (46.4%) achieved partial response (PR). By using Kaplan Meier's method the mean survival time was 19.8 months. One year survival was 66.6 per cent. Non hematologic toxicity consisted of mild nausea, vomiting, alopecia and hyperpigmentation of the skin. Rising creatinine of grade I was seen in 1.6 per cent. Anemia and leukopenia were common hematologic side effects with 27.5 per cent and 14.2 per cent of patients experiencing grade III and IV toxicity respectively. Both side effects were usually short lived and responsible for the delay of gemcitabine administration on day 8 and 15 in 18.3 per cent and 23.3 per cent on day 15 alone of chemotherapeutic courses respectively. We conclude that the combination of gemcitabine and cisplatin at this dosage achieved good response with moderate side effects.
format Article
author Thongprasert S.
Chewaskulyong B.
Pothirat C.
spellingShingle Thongprasert S.
Chewaskulyong B.
Pothirat C.
Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
author_facet Thongprasert S.
Chewaskulyong B.
Pothirat C.
author_sort Thongprasert S.
title Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
title_short Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
title_full Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
title_fullStr Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
title_full_unstemmed Combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
title_sort combination of gemcitabine and cisplatin in advanced non-small cell lung cancer
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0034849569&partnerID=40&md5=b3a2dbd695d69b2add961e0a458f9817
http://www.ncbi.nlm.nih.gov/pubmed/11460942
http://cmuir.cmu.ac.th/handle/6653943832/1983
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