Prenatal diagnosis of hemoglobin Bart's hydrops fetalis by HPLC analysis of hemoglobin in fetal blood samples

• Main Authors: Sanguansermsri T., Thanaratanakorn P., Steger H.F., Tongsong T., Sirivatanapa P., Wanapirak C., Sirichotiyakul S., Chanprapas P., Flatz G.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035288564&partnerID=40&md5=be1b9b8ad4f39da18b727d03bc80aae4; http://www.ncbi.nlm.nih.gov/pubmed/11485083; http://cmuir.cmu.ac.th/handle/6653943832/1987
• Institution: Chiang Mai University

Since HbF and HbA are not found in fetuses with Hb Bart's hydrops fetalis the feasibility of prenatal diagnosis of homozygous α-thalassemia 1 by fetal hemoglobin typing was examined. Blood samples were obtained from fetuses at 18 to 22 weeks of gestation by cordocentesis in 32 pregnant women at...