Update on clinical radiobiology
Radiation therapy is an important local cytotoxic modality for cancer treatment whose aim is to control the disease while minimising damage to normal tissue. The combination of different treatment modalities offers a more effective cure and reduction in normal tissue toxicity. However, the differenc...
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2014
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th-cmuir.6653943832-20042014-08-30T02:00:22Z Update on clinical radiobiology Chawapun N. Radiation therapy is an important local cytotoxic modality for cancer treatment whose aim is to control the disease while minimising damage to normal tissue. The combination of different treatment modalities offers a more effective cure and reduction in normal tissue toxicity. However, the differences in genetic profiles can cause diverse treatment outcomes. Multidisciplinary research, where technologies and knowledge from different areas are integrated, is necessary to design the optimal regimen for individualised cancer treatment. This paper offers an overview of some new cancer treatment strategies; the impact of molecular imaging on radiation oncology; and a computer simulation model to optimise treatment planning based on patient information. It briefly discusses molecular targeted therapy, tumour microenvironment and bioreductive agents, and evidence for making individualised medicine a reality. Using DNA microarrays and proteomic technologies, information on defined molecular targets and genetic profiling for individual patients can be obtained and new algorithms for radiation oncology-related diagnosis, treatment response and prognosis can be developed. © 2006 Biomedical Imaging and Intervention Journal. All rights reserved. 2014-08-30T02:00:22Z 2014-08-30T02:00:22Z 2006 Review 18235530 10.2349/biij.2.1.e22 http://www.scopus.com/inward/record.url?eid=2-s2.0-57049159912&partnerID=40&md5=528734c16dd503884ee93b6817b98bab http://cmuir.cmu.ac.th/handle/6653943832/2004 English |
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Radiation therapy is an important local cytotoxic modality for cancer treatment whose aim is to control the disease while minimising damage to normal tissue. The combination of different treatment modalities offers a more effective cure and reduction in normal tissue toxicity. However, the differences in genetic profiles can cause diverse treatment outcomes. Multidisciplinary research, where technologies and knowledge from different areas are integrated, is necessary to design the optimal regimen for individualised cancer treatment. This paper offers an overview of some new cancer treatment strategies; the impact of molecular imaging on radiation oncology; and a computer simulation model to optimise treatment planning based on patient information. It briefly discusses molecular targeted therapy, tumour microenvironment and bioreductive agents, and evidence for making individualised medicine a reality. Using DNA microarrays and proteomic technologies, information on defined molecular targets and genetic profiling for individual patients can be obtained and new algorithms for radiation oncology-related diagnosis, treatment response and prognosis can be developed. © 2006 Biomedical Imaging and Intervention Journal. All rights reserved. |
format |
Review |
author |
Chawapun N. |
spellingShingle |
Chawapun N. Update on clinical radiobiology |
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Chawapun N. |
author_sort |
Chawapun N. |
title |
Update on clinical radiobiology |
title_short |
Update on clinical radiobiology |
title_full |
Update on clinical radiobiology |
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Update on clinical radiobiology |
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Update on clinical radiobiology |
title_sort |
update on clinical radiobiology |
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2014 |
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http://www.scopus.com/inward/record.url?eid=2-s2.0-57049159912&partnerID=40&md5=528734c16dd503884ee93b6817b98bab http://cmuir.cmu.ac.th/handle/6653943832/2004 |
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