Can adenocarcinoma in situ of the uterine cervix be predicted before cervical conization?
This study was undertaken to determine the effectiveness of the Papanicolaou (Pap) smear, colposcopically-directed biopsy (CDB), and endocervical curettage (ECC) in preconization detection of adenocarcinoma in situ (AIS) of the uterine cervix. Women, whose cervical conization specimens contained ade...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2014
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| Online Access: | http://www.scopus.com/inward/record.url?eid=2-s2.0-33947514224&partnerID=40&md5=8798cd9cbd20c8aa457c8a44b70f5a93 http://www.ncbi.nlm.nih.gov/pubmed/17250421 http://cmuir.cmu.ac.th/handle/6653943832/2033 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | This study was undertaken to determine the effectiveness of the Papanicolaou (Pap) smear, colposcopically-directed biopsy (CDB), and endocervical curettage (ECC) in preconization detection of adenocarcinoma in situ (AIS) of the uterine cervix. Women, whose cervical conization specimens contained adenocarcinoma in situ without any associated invasive lesion at Chiang Mai University Hospital between March 1998 and March 2006, were reviewed. During the study period, fifty-one women who matched the study inclusion were identified. Glandular abnormality was detected by Pap smears in 22 women (43.1%). Among 29 women with squamous lesions on Pap smears, 9 additional glandular abnormalities were detected on CDB and/or ECC. In total, glandular abnormality was suspected in 31 women (60.8%) preoperatively. According to the histological type of AIS, glandular abnormality suspected from preoperative evaluation was noted in 20 women (70.4%) who had pure AIS. Among women with mixed AIS/HSIL, only 12 women (50.0%) had preoperative evaluation suggesting glandular abnormality. These data demonstrate that the sensitivity of combining Pap smear, CDB and/or ECC in detecting glandular lesions before conization containing AIS appears to be suboptimal. Further study concerning the improvement of detecting AIS before conization is warranted to select the most appropriate diagnostic conization method for such lesions. |
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