Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
Objective: To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital Material and Method: A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and trea...
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th-cmuir.6653943832-20412014-08-30T02:00:25Z Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital Srivichai K. Uttavichai C. Tongsong T. Objective: To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital Material and Method: A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and treatment with single-dose methotrexate according to the protocol of Stovall et al between 1996 and 2005. The successful treatment was defined as no need for surgical intervention. Results: As many as 96 out of 106 (90.6%) were successfully treated with methotrexate, though four required a second dose. Pretreatment β-human chorionic gonadotropin (β-hCG) levels were significantly lower in women who responded to single-dose therapy than either in those who required two doses or who had a failure of medical management (p < 0.01). The mean pretreatment level of β-hCG was 873 mlU/ml. The median time to resolution of β-hCG was 21 days. In addition, all cases with failed medical treatment had adnexal masses larger than 3.5 centimeters in diameter. Conclusion: In the present series, treatment of ectopic pregnancy with single-dose methotrexate was as high as 90% successful. Women with a high pretreatment β-hCG level and large sonographic adnexal masses had a greater probability of requiring either surgical intervention or multiple doses of methotrexate. 2014-08-30T02:00:25Z 2014-08-30T02:00:25Z 2006 Article 01252208 17128828 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-33750974814&partnerID=40&md5=adfaedb6ccf11729d8cccb3dcb33af54 http://www.ncbi.nlm.nih.gov/pubmed/17128828 http://cmuir.cmu.ac.th/handle/6653943832/2041 English |
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Objective: To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital Material and Method: A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and treatment with single-dose methotrexate according to the protocol of Stovall et al between 1996 and 2005. The successful treatment was defined as no need for surgical intervention. Results: As many as 96 out of 106 (90.6%) were successfully treated with methotrexate, though four required a second dose. Pretreatment β-human chorionic gonadotropin (β-hCG) levels were significantly lower in women who responded to single-dose therapy than either in those who required two doses or who had a failure of medical management (p < 0.01). The mean pretreatment level of β-hCG was 873 mlU/ml. The median time to resolution of β-hCG was 21 days. In addition, all cases with failed medical treatment had adnexal masses larger than 3.5 centimeters in diameter. Conclusion: In the present series, treatment of ectopic pregnancy with single-dose methotrexate was as high as 90% successful. Women with a high pretreatment β-hCG level and large sonographic adnexal masses had a greater probability of requiring either surgical intervention or multiple doses of methotrexate. |
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Article |
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Srivichai K. Uttavichai C. Tongsong T. |
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Srivichai K. Uttavichai C. Tongsong T. Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital |
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Srivichai K. Uttavichai C. Tongsong T. |
author_sort |
Srivichai K. |
title |
Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital |
title_short |
Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital |
title_full |
Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital |
title_fullStr |
Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital |
title_full_unstemmed |
Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital |
title_sort |
medical treatment of ectopic pregnancy: a ten-year review of 106 cases at maharaj nakorn chiang mai hospital |
publishDate |
2014 |
url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-33750974814&partnerID=40&md5=adfaedb6ccf11729d8cccb3dcb33af54 http://www.ncbi.nlm.nih.gov/pubmed/17128828 http://cmuir.cmu.ac.th/handle/6653943832/2041 |
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