Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital

Objective: To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital Material and Method: A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and trea...

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Main Authors: Srivichai K., Uttavichai C., Tongsong T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-33750974814&partnerID=40&md5=adfaedb6ccf11729d8cccb3dcb33af54
http://www.ncbi.nlm.nih.gov/pubmed/17128828
http://cmuir.cmu.ac.th/handle/6653943832/2041
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-20412014-08-30T02:00:25Z Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital Srivichai K. Uttavichai C. Tongsong T. Objective: To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital Material and Method: A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and treatment with single-dose methotrexate according to the protocol of Stovall et al between 1996 and 2005. The successful treatment was defined as no need for surgical intervention. Results: As many as 96 out of 106 (90.6%) were successfully treated with methotrexate, though four required a second dose. Pretreatment β-human chorionic gonadotropin (β-hCG) levels were significantly lower in women who responded to single-dose therapy than either in those who required two doses or who had a failure of medical management (p < 0.01). The mean pretreatment level of β-hCG was 873 mlU/ml. The median time to resolution of β-hCG was 21 days. In addition, all cases with failed medical treatment had adnexal masses larger than 3.5 centimeters in diameter. Conclusion: In the present series, treatment of ectopic pregnancy with single-dose methotrexate was as high as 90% successful. Women with a high pretreatment β-hCG level and large sonographic adnexal masses had a greater probability of requiring either surgical intervention or multiple doses of methotrexate. 2014-08-30T02:00:25Z 2014-08-30T02:00:25Z 2006 Article 01252208 17128828 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-33750974814&partnerID=40&md5=adfaedb6ccf11729d8cccb3dcb33af54 http://www.ncbi.nlm.nih.gov/pubmed/17128828 http://cmuir.cmu.ac.th/handle/6653943832/2041 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To evaluate the effectiveness of single-dose intramuscular methotrexate in the treatment of ectopic pregnancy at Maharaj Nakorn Chiang Mai Hospital Material and Method: A retrospective review of the patient records was performed on the patients with diagnosis of ectopic pregnancy and treatment with single-dose methotrexate according to the protocol of Stovall et al between 1996 and 2005. The successful treatment was defined as no need for surgical intervention. Results: As many as 96 out of 106 (90.6%) were successfully treated with methotrexate, though four required a second dose. Pretreatment β-human chorionic gonadotropin (β-hCG) levels were significantly lower in women who responded to single-dose therapy than either in those who required two doses or who had a failure of medical management (p < 0.01). The mean pretreatment level of β-hCG was 873 mlU/ml. The median time to resolution of β-hCG was 21 days. In addition, all cases with failed medical treatment had adnexal masses larger than 3.5 centimeters in diameter. Conclusion: In the present series, treatment of ectopic pregnancy with single-dose methotrexate was as high as 90% successful. Women with a high pretreatment β-hCG level and large sonographic adnexal masses had a greater probability of requiring either surgical intervention or multiple doses of methotrexate.
format Article
author Srivichai K.
Uttavichai C.
Tongsong T.
spellingShingle Srivichai K.
Uttavichai C.
Tongsong T.
Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
author_facet Srivichai K.
Uttavichai C.
Tongsong T.
author_sort Srivichai K.
title Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
title_short Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
title_full Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
title_fullStr Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
title_full_unstemmed Medical treatment of ectopic pregnancy: A ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital
title_sort medical treatment of ectopic pregnancy: a ten-year review of 106 cases at maharaj nakorn chiang mai hospital
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-33750974814&partnerID=40&md5=adfaedb6ccf11729d8cccb3dcb33af54
http://www.ncbi.nlm.nih.gov/pubmed/17128828
http://cmuir.cmu.ac.th/handle/6653943832/2041
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